Dendrimers as anti-inflammatory agents

被引：20

作者：

Avti, Pramod K. ^{[1
,2
,3
]}

Kakkar, Ashok ^{[3
]}

机构：

[1] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada

[2] Ecole Polytech, Inst Biomed Engn, Montreal, PQ H3C 3A7, Canada

[3] McGill Univ, Dept Chem, Fac Sci, Montreal, PQ H3A 0B8, Canada

来源：

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2013年 / 49卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Dendrimers; Nanocarriers; Anti-inflammatory agents; Cyclooxygenase (COX-2); Inducible nitric oxide synthase (iNOS); Pro-inflammatory cytokines; CAPSID PROTEIN; MOLECULAR ARCHITECTURE; ENERGY-TRANSFER; INHIBITORS; POLYMERS; CELLS; DIMERIZATION; MICROBICIDE; DELIVERY; PEPTIDE;

D O I：

10.1590/S1984-82502013000700006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dendrimers constitute an intriguing class of macromolecules which find applications in a variety of areas including biology. These hyperbranched macromolecules with tailored backbone and surface groups have been extensively investigated as nanocarriers for gene and drug delivery, by molecular encapsulation or covalent conjugation. Dendrimers have provided an excellent platform to develop multivalent and multifunctional nanoconjugates incorporating a variety of functional groups including drugs which are known to be anti-inflammatory agents. Recently, dendrimers have been shown to possess anti-inflammatory properties themselves. This unexpected and intriguing discovery has provided an additional impetus in designing novel active pharmaceutical agents. In this review, we highlight some of the recent developments in the field of dendrimers as nanoscale anti-inflammatory agents.

引用

页码：57 / 65

页数：9

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