Efficacy of Proveblue (Methylene Blue) in an Experimental Cerebral Malaria Murine Model

被引：18

作者：

Dormoi, Jerome ^{[1
,2
]}

Briolant, Sebastien ^{[1
,2
,3
,4
]}

Desgrouas, Camille ^{[5
]}

Pradines, Bruno ^{[1
,2
]}

机构：

[1] Inst Rech Biomed Armees, Dept Infect Terrain, Unite Parasitol, Marseille, France

[2] Aix Marseille Univ, UM 63, INSERM 1095,IRD 198, Unite Rech Malad Infect & Trop Emergentes,,CNRS 7, Marseille, France

[3] Direct Interarmees Serv Sante, Cayenne, French Guiana

[4] Inst Pasteur, Parasitol Lab, Cayenne, French Guiana

[5] Inst Rech Biomed Armees, UMR MD3, Marseille, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 07期

关键词：

SEVERE FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; RANDOMIZED-TRIAL; WESTERN CAMBODIA; CHLOROQUINE; COMBINATION; ARTESUNATE; RESISTANCE; QUININE; MICE;

D O I：

10.1128/AAC.02381-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although 100%of untreated mice infected with Plasmodium berghei died with specific signs of cerebral malaria and 100% of mice treated with 3 mg/kg dihydroartemisinin, the active metabolite of artesunate, which is used as the first-line treatment for severe malaria, also died but showed no specific signs of cerebral malaria, 78% of mice treated with 10 mg/kg Proveblue (methylene blue) and 78% of mice treated with a combination of 3 mg dihydroartemisinin and 10 mg/kg Proveblue survived and showed no specific signs of cerebral malaria or detectable parasites.

引用

页码：3412 / 3414

页数：3

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