A novel series of N-acyl substituted indole-linked benzimidazoles and naphthoimidazoles as potential anti inflammatory, anti biofilm and anti microbial agents

被引：31

作者：

Abraham, Rajan ^{[1
]}

Periakaruppan, Prakash ^{[1
]}

Mahendran, Karthikeyan ^{[2
]}

Ramanathan, Murugappan ^{[2
]}

机构：

[1] Thiagarajar Coll, Dept Chem, Madurai 625009, Tamil Nadu, India

[2] Thiagarajar Coll, Dept Zool & Microbiol, Madurai 625009, Tamil Nadu, India

来源：

MICROBIAL PATHOGENESIS | 2018年 / 114卷

关键词：

Indole-linked benzimidazoles; Indole-linked naphthoimidazoles; Anti inflammatory; Anti biofilm activity; Anti microbial activity; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; INHIBITORS; DESIGN; IDENTIFICATION; NUCLEOSIDES; RESISTANCE; MODEL; MRSA;

D O I：

10.1016/j.micpath.2017.12.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel N-acyl substituted indole-linked benzimidazoles and naphthoimidazoles were synthesized. Their chemical structures were confirmed using spectroscopic tools including H-1 NMR, C-13 NMR and CHN-elemental analyses. Anti inflammatory activity for all target compounds was evaluated in-vitro. The synthesized compounds hinder the biofilm formation and control the growth of the pathogen, Staphylococcus epidermis. Anti microbial activity of the compounds was evaluated against both Gram negative and Gram positive bacteria such as Staphylococcus aureus (MTCC 2940), Pseudomonas aeruginosa (MTCC424), Escherchia coli (MTCC 443) and Enterococcus fecalis.

引用

页码：409 / 413

页数：5

共 34 条

[1]

Alamgir M, 2007, TOP HETEROCYCL CHEM, V9, P87, DOI 10.1007/7081_2007_088

[2] A parallel-group comparison of astemizole and loratadine for the treatment of perennial allergic rhinitis [J].

AlMuhaimeed, H .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1997, 25 (04) :175-181

[3] Selective NR1/2B N-Methyl-d-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides [J].

Borza, Istvan ;

Bozo, Eva ;

Barta-Szalai, Gizella ;

Kiss, Csilla ;

Tarkanyi, Gabor ;

Demeter, Adam ;

Gati, Tamas ;

Hada, Viktor ;

Kolok, Sandor ;

Gere, Aniko ;

Fodor, Laszlo ;

Nagy, Jozsef ;

Galgoczy, Kornel ;

Magdo, Ildiko ;

Agai, Bela ;

Fetter, Jozsef ;

Bertha, Ferenc ;

Keseru, Gyorgy M. ;

Horvath, Csilla ;

Farkas, Sandor ;

Greiner, Istvan ;

Domany, Gyorgy .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (05) :901-914

[4] Biofilms:: the matrix revisited [J].

Branda, SS ;

Vik, Å ;

Friedman, L ;

Kolter, R .

TRENDS IN MICROBIOLOGY, 2005, 13 (01) :20-26

[5] Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria [J].

Bunders, Cynthia A. ;

Richards, Justin J. ;

Melander, Christian .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (12) :3797-3800

[6] ADHERENCE OF COAGULASE-NEGATIVE STAPHYLOCOCCI TO PLASTIC TISSUE-CULTURE PLATES - A QUANTITATIVE MODEL FOR THE ADHERENCE OF STAPHYLOCOCCI TO MEDICAL DEVICES [J].

CHRISTENSEN, GD ;

SIMPSON, WA ;

YOUNGER, JJ ;

BADDOUR, LM ;

BARRETT, FF ;

MELTON, DM ;

BEACHEY, EH .

JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 22 (06) :996-1006

[7] Benzimidazole: An emerging scaffold for analgesic and anti-inflammatory agents [J].

Gaba, Monika ;

Singh, Sarbjot ;

Mohan, Chander .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 76 :494-505

[8] Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines [J].

Göker, H ;

Özden, S ;

Yildiz, S ;

Boykin, DW .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (10) :1062-1069

[9] Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species [J].

Göker, H ;

Kus, C ;

Boykin, DW ;

Yildiz, S ;

Altanlar, N .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (08) :2589-2596

[10] Drug therapy - Antimicrobial-drug resistance [J].

Gold, HS ;

Moellering, RC .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (19) :1445-1453

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