Aromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activity

被引：30

作者：

Venditti, Alessandro ^{[1
]}

Serrilli, Anna Maria ^{[1
]}

Rizza, Luisa ^{[2
]}

Frasca, Giuseppina ^{[3
]}

Cardile, Venera ^{[3
]}

Bonina, Francesco Paolo ^{[2
]}

Bianco, Armandodoriano ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[2] Univ Catania, Dipartimento Sci Farmaco, I-95125 Catania, Italy

[3] Univ Catania, Dipartimento Sci Biomed, Sez Fisiol, I-95125 Catania, Italy

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 4-5期

关键词：

aromadendrine; flavonoids; dihydroflavonol; Olea europaea; INTERCELLULAR-ADHESION MOLECULE-1; COLONY-STIMULATING FACTOR; INFLAMMATORY RESPONSES; EXPRESSION; MODULATION; LEAVES;

D O I：

10.1080/14786419.2012.693924

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Leaves of Olea europaea, cultivar Nocellara del Belice, were examined with respect to the medium-polar fraction, obtained by an ethyl acetate extraction of the whole extract. In the medium polar fraction, we isolated the two hydroxy-phenyl-ethyl alcohols (hydroxyl-tyrosol and tyrosol) that are the main component of olives. In addition, we isolated a flavonoidic compound, aromadendrine, a dihydroflavonol yet known but quite rare in nature. It is the first time that aromadendrine is isolated in O. europaea and we studied the aromadendrine biological activity. In particular, the ability of aromadendrine to reduce the inflammation induced in normal keratinocytes using an invitro cell model was evaluated. The results of the present research indicate aromadendrine as a novel component in O. europaea with effective activity against skin inflammation.

引用

页码：340 / 349

页数：10

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