Engineering biocompatible implant surfaces Part I: Materials and surfaces

被引:572
作者
Bauer, Sebastian [1 ]
Schmuki, Patrik [1 ]
von der Mark, Klaus [2 ]
Park, Jung [3 ]
机构
[1] Univ Erlangen Nurnberg, Inst Surface Sci & Corros LKO, Dept Mat Sci, D-91058 Erlangen, Germany
[2] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, Dept Expt Med 1, D-91054 Erlangen, Germany
[3] Univ Hosp Erlangen, Div Mol Pediat, Dept Pediat, Erlangen, Germany
关键词
SELF-ASSEMBLED MONOLAYERS; CALCIUM-PHOSPHATE COATINGS; OSTEOBLAST-LIKE CELLS; CO-CR-MO; CERAMIC BALL HEADS; HYDROXYAPATITE-COATED IMPLANTS; FRETTING-CORROSION BEHAVIOR; STIMULATES BONE ONGROWTH; TITANIUM DENTAL IMPLANTS; GLOW-DISCHARGE PLASMA;
D O I
10.1016/j.pmatsci.2012.09.001
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
During recent decades vast and continuously increasing numbers of biomedical implants have been introduced for continuous use in the human body. Since the early cemented hip replacements in the 1960s there has been a constant spread of new materials, and ever more complex designs are being used in these implant devices. But still the rate of failure and loss of implants is undesirably high and leaves space for improvements. The challenge is to understand the interactions of implant surface with the surrounding tissue sufficiently, to actively tailor desired interactions. Bulk and surface properties of biomaterials used for implants have been shown to directly influence, and in some cases, control the dynamic interactions that take place at the tissue implant interface. It is critical to recognize that synthetic materials have specific bulk and surface properties or characteristics that determine their in vitro and in vivo characteristics. This article reviews the interdisciplinary field of biocompatible implant surfaces from the viewpoint of materials science, biochemistry and cell biology. It compiles an overview on basic information about bulk and surface properties of implants based on metallic materials (particularly titanium and its alloys) and surface modification including functionalization with adhesion and growth promoting species. It describes how cells recognize surfaces and respond to different biomaterials, outlines common assays on cell behavior in culture, and reports on cell types and proteins involved in tissue response, acute and chronic responses to implanted biomaterials. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:261 / 326
页数:66
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