Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

被引：509
作者：
Deng, Chao
Jiang, Yanjiao
Cheng, Ru
Meng, Fenghua
Zhong, Zhiyuan [1 ]
机构：
[1] Soochow Univ, Biomed Polymers Lab, Suzhou 215123, Peoples R China
来源：
NANO TODAY | 2012年 / 7卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Anticancer drugs; Biodegradable micelles; Controlled drug release; Targeted delivery; Cancer therapy; BLOCK-COPOLYMER MICELLES; VIVO ANTITUMOR-ACTIVITY; CROSS-LINKED MICELLES; ACIDIC SOLID TUMORS; INTRACELLULAR DRUG; IN-VIVO; PHASE-I; CANCER-THERAPY; MULTIDRUG-RESISTANCE; TRIGGERED RELEASE;
D O I：
10.1016/j.nantod.2012.08.005
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted and controlled anticancer drug delivery due to their excellent biocompatibility, prolonged circulation time, enhanced accumulation in tumor, and in vivo degradability. Notably, several micellar anticancer drugs, with clear advantages of decreased side effects and improved drug tolerance, have advanced to different phases of clinical trials. The therapeutic outcomes are, however, far from optimal, due to issues of low in vivo stability, poor tumor penetration, inefficient cellular uptake, slow intracellular drug release, etc. This review high-lights recent developments in functional biodegradable micelles for safe and efficient cancer chemotherapy. (c) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：467 / 480
页数：14
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