Pregnancy history and incidence of melanoma in women: A pooled analysis

被引:61
作者
Karagas, MR
Zens, MS
Stukel, TA
Swerdlow, AJ
Rosso, S
Osterlind, A
Mack, T
Kirkpatrick, C
Holly, EA
Green, A
Gallagher, R
Elwood, JM
Armstrong, BK
机构
[1] Dartmouth Coll Sch Med, Sect Biostat & Epidemiol, Dept Community & Family Med, Lebanon, NH 03756 USA
[2] Inst Clin Evaluat Sci, Toronto, ON M4N 3M5, Canada
[3] Inst Canc Res, Epidemiol Sect, Sutton SM2 5NG, Surrey, England
[4] Registro Tumori Piemonte, I-10123 Turin, Italy
[5] Dermatol Clin, DK-3400 Hillerod, Denmark
[6] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA
[7] Good Samaritan Hosp, Puyallup, WA 98371 USA
[8] Queensland Inst Med Res, Brisbane, Qld 4029, Australia
[9] Canc Control Agcy British Colombia, Epidemiol Sect, Vancouver, BC V52 4E6, Canada
[10] New S Wales Canc Council, Canc Res & Registers, Kings Cross 1340, Australia
[11] Univ Sydney, Sydney, NSW 2006, Australia
关键词
case-control studies; data pooling; melanoma; parity;
D O I
10.1007/s10552-005-0281-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
There is evidence that pregnancy history including age at first birth and parity may play a role in risk of cutaneous melanoma in women, although, epidemiological findings are inconsistent. We conducted a collaborative analysis of these factors using the original data from ten completed case-control studies (2391 cases and 3199 controls), and assessed the potential confounding effects of socioeconomic, pigmentary, and sun exposure-related factors. We found no overall association with ever having a live birth (pooled odds ratio (pOR) 0.95, 95% confidence interval (CI) 0.67-1.35). However, we detected a reduced risk of melanoma among women with higher parity (>= 5 versus no live births pOR 0.76, 95% CI 0.49-1.18, each live birth pOR 0.95, 95% CI 0.91-0.99, p trend = 0.05). Women with both earlier age at first birth (e.g., < 20 years) and higher parity (e.g., >= 5 live births) had a particularly lower risk than women with later age at first birth (e.g., >= 25 years) and lower parity (e.g., < 5 live births) (pOR 0.33, 95% CI 0.14-0.75). The results are compatible with an effect of reproductive history-related factors on melanoma risk, but also could reflect differences in other factors, such as sun exposure history.
引用
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页码:11 / 19
页数:9
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