The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer

被引：163

作者：

Anisimov, Vladimir N. ^{[1
]}

Bartke, Andrzej ^{[2
]}

机构：

[1] NN Petrov Oncol Res Inst, Dept Carcinogenesis & Oncogerontol, St Petersburg 197758, Russia

[2] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2013年 / 87卷 / 03期

关键词：

Growth hormone; IGF-1; Antidiabetic biguanides; Aging; Cancer prevention; EXTENDS LIFE-SPAN; AMES DWARF MICE; CALORIC RESTRICTION MIMETICS; FATAL NEOPLASTIC DISEASES; SINGLE-GENE MUTATIONS; FACTOR-I LEVELS; BREAST-CANCER; OXIDATIVE STRESS; DIETARY RESTRICTION; INSULIN-RECEPTOR;

D O I：

10.1016/j.critrevonc.2013.01.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. GH/Insulin/insulin-like growth factor-1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases lifespan in nematodes, fruit flies and mice. The life-prolonging effects of caloric restriction are likely related to decreasing IGF-1 levels. Evidence has emerged that antidiabetic drugs are promising candidates for both lifespan extension and prevention of cancer. Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore, metformin seems to decrease the risk for cancer in diabetic patients. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：201 / 223

页数：23

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