Prostate-specific membrane antigen radioligand therapy of prostate cancer

被引：7

作者：

Beheshti, Mohsen ^{[1
,2
]}

Heinzel, Alexander ^{[1
]}

von Mallek, Dirk ^{[1
]}

Filss, Christian ^{[1
]}

Mottaghy, Felix M. ^{[1
,3
]}

机构：

[1] RWTH Univ, Univ Hosp, Dept Nucl Med, Pauwelsstr 30, D-52074 Aachen, Germany

[2] Paracelsus Med Univ, Dept Nucl Med & Endocrinol, Salzburg, Austria

[3] Maastricht Univ, Dept Radiol & Nucl Med, Med Ctr, Maastricht, Netherlands

来源：

QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2019年 / 63卷 / 01期

关键词：

Prostatic neoplasms; Lu-177-PSMA-617; Radiotherapy; TARGETED ALPHA-THERAPY; RADIATION-DOSIMETRY; PSMA LIGANDS; PRECLINICAL EVALUATION; RADIONUCLIDE THERAPY; PHASE-II; BIODISTRIBUTION; INHIBITORS; PET; ANTIBODY;

D O I：

10.23736/S1824-4785.19.03155-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Defining an optimal therapeutic approach in metastatic castration-resistance prostate cancer (mCRPC) patients in advanced stages is still chal-lengina in routine clinical practice. Prostate-specific membrane antigen (PSMA) targeted radionuclide therapy with beta- or alpha-emitters such as 177-Lutethium (Lu-177) or 225-Actinium ((225)A) has been a main focus at multiple academic research centers in the last few years. This review article provides an overview of PSMA characteristics. clinical performance, safety and toxicity of PSMA targeted beta- or alpha-radiation therapy.

引用

页码：29 / 36

页数：8

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