Cross-Hemispheric Functional Connectivity in the Human Fetal Brain

被引：150

作者：

Thomason, Moriah E. ^{[1
,2
,3
]}

Dassanayake, Maya T. ^{[4
]}

Shen, Stephen ^{[5
]}

Katkuri, Yashwanth ^{[6
]}

Alexis, Mitchell ^{[4
]}

Anderson, Amy L. ^{[1
,3
]}

Yeo, Lami ^{[3
,7
]}

Mody, Swati ^{[6
]}

Hernandez-Andrade, Edgar ^{[3
,7
]}

Hassan, Sonia S. ^{[3
,7
]}

Studholme, Colin ^{[8
,9
]}

Jeong, Jeong-Won ^{[2
,10
]}

Romero, Roberto ^{[3
,11
]}

机构：

[1] Wayne State Univ, Merrill Palmer Skillman Inst Child & Family Dev, Detroit, MI 48202 USA

[2] Wayne State Univ, Dept Pediat, Sch Med, Detroit, MI 48202 USA

[3] Natl Inst Child Hlth & Human Dev NICHD, Perinatol Res Branch, NIH, US Dept HHS, Detroit, MI 48202 USA

[4] Wayne State Univ, Basic Med Sci Program, Sch Med, Detroit, MI 48202 USA

[5] Wayne State Univ, Sch Med, Detroit, MI 48202 USA

[6] Wayne State Univ, Dept Radiol, Sch Med, Detroit, MI 48202 USA

[7] Wayne State Univ, Dept Obstet & Gynecol, Sch Med, Detroit, MI 48202 USA

[8] Univ Washington, Dept Pediat & Neonatol, Seattle, WA 98105 USA

[9] Univ Washington, Dept Bioengn, Seattle, WA 98105 USA

[10] Wayne State Univ, Dept Neurol, Sch Med, Detroit, MI 48202 USA

[11] NICHD, Perinatol Res Branch, NIH, US Dept HHS, Bethesda, MD 20814 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2013年 / 5卷 / 173期

关键词：

RESTING-STATE NETWORKS; LOW-FREQUENCY FLUCTUATIONS; DEFAULT-MODE; CINGULATE CORTEX; INFANT BRAIN; IN-UTERO; EXPOSURE; FETUS; EMERGENCE; DISORDER;

D O I：

10.1126/scitranslmed.3004978

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Compelling evidence indicates that psychiatric and developmental disorders are generally caused by disruptions in the functional connectivity (FC) of brain networks. Events occurring during development, and in particular during fetal life, have been implicated in the genesis of such disorders. However, the developmental timetable for the emergence of neural FC during human fetal life is unknown. We present the results of resting-state functional magnetic resonance imaging performed in 25 healthy human fetuses in the second and third trimesters of pregnancy (24 to 38 weeks of gestation). We report the presence of bilateral fetal brain FC and regional and age-related variation in FC. Significant bilateral connectivity was evident in half of the 42 areas tested, and the strength of FC between homologous cortical brain regions increased with advancing gestational age. We also observed medial to lateral gradients in fetal functional brain connectivity. These findings improve understanding of human fetal central nervous system development and provide a basis for examining the role of insults during fetal life in the subsequent development of disorders in neural FC.

引用

页数：10

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