Clinicopathological Significance of Mesothelin Expression in Invasive Breast Cancer

被引：17
作者：
Wang, L. [2 ]
Niu, Z. [2 ]
Zhang, L. [2 ]
Liu, X. [1 ]
Wang, X. [1 ]
Li, F. [1 ]
Wang, Y. [1 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Qingdao Med Coll, Ctr Breast Dis, Qingdao 266003, Shandong, Peoples R China
[2] Tianjin Union Med Ctr, Dept Breast & Thyroid Dis, Tianjin, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2012年 / 40卷 / 03期
关键词：
BREAST CANCER; METASTASIS; MESOTHELIN; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2/NEU); OESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; LYMPH NODE; OVERALL SURVIVAL; PROLONGED PATIENT SURVIVAL; MONOCLONAL-ANTIBODY; OVARIAN CANCERS; HER-2/NEU; DIAGNOSIS; ADENOCARCINOMAS; PANCREAS; ESTROGEN; BINDING;
D O I：
10.1177/147323001204000309
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
OBJECTIVES: This study evaluated the expression profile of the mesothelin (MSLN) gene and its prognostic significance in breast cancer. METHODS: To evaluate the diagnostic and prognostic significance of mesothelin, immunohistochemistry was used to assess the level of mesothelin protein in surgically resected, formalin-fixed, paraffin-embedded invasive breast carcinoma specimens. Associations between mesothelin and other biomarkers, including oestrogen receptor (OR), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2/neu), were also evaluated. RESULTS: A total of 182 breast carcinoma specimens were included. Mesothelin protein was present in the membrane of malignant cells. There was correlation between the presence of mesothelin in tumour cells and tumour infiltration of the lymph node. There was no correlation between the presence of mesothelin and HER2/neu protein, OR and PR in tumour cells. Mesothelin levels were significantly associated with decreased overall survival. CONCLUSIONS: Lymph node status, tumour size, HER2/neu and mesothelin protein levels in breast cancer cells were independent prognostic factors. Mesothelin could be useful as a prognostic marker of overall survival in invasive breast cancer.
引用
收藏
页码：909 / 916
页数：8
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