Hippocampal synaptic plasticity, spatial memory and anxiety

被引：524

作者：

Bannerman, David M. ^{[1
]}

Sprengel, Rolf ^{[2
]}

Sanderson, David J. ^{[3
]}

McHugh, Stephen B. ^{[1
]}

Rawlins, J. Nicholas P. ^{[1
]}

Monyer, Hannah

Seeburg, Peter H. ^{[2
]}

机构：

[1] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England

[2] Max Planck Inst Med Res, D-69120 Heidelberg, Germany

[3] Univ Durham, Dept Psychol, Durham DH1 3LE, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 03期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

LONG-TERM POTENTIATION; ASPARTATE RECEPTOR ANTAGONIST; FREELY MOVING RATS; CA3 NMDA RECEPTORS; A-DEFICIENT MICE; VENTRAL HIPPOCAMPUS; ENTORHINAL CORTEX; WORKING-MEMORY; DENTATE GYRUS; DOUBLE DISSOCIATION;

D O I：

10.1038/nrn3677

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

引用

页码：181 / 192

页数：12

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