Risk factors for Staphylococcus aureus nasal colonization in Danish middle-aged and elderly twins

被引：24
作者：
Andersen, P. S. [1 ]
Larsen, L. A. [2 ]
Fowler, V. G., Jr. [3 ]
Stegger, M. [1 ]
Skov, R. L. [1 ]
Christensen, K. [2 ,4 ,5 ]
机构：
[1] Statens Serum Inst, DK-2300 Copenhagen, Denmark
[2] Univ So Denmark, Inst Publ Hlth, Danish Twin Registry, Odense, Denmark
[3] Duke Univ, Duke Med Ctr, Durham, NC USA
[4] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
[5] Odense Univ Hosp, Dept Clin Biochem & Pharmacol, DK-5000 Odense, Denmark
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2013年 / 32卷 / 10期
基金：
美国国家卫生研究院;
关键词：
ATOPIC-DERMATITIS; UNITED-STATES; HOST GENETICS; CARRIAGE; PREVALENCE; INFECTIONS; BACTEREMIA; PSORIASIS; HUMANS; ADULTS;
D O I：
10.1007/s10096-013-1882-0
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Staphylococcus aureus is a human commensal bacterium found in the nasal cavity and other body sites. Identifying risk factors for S. aureus nasal carriage is of interest, as nasal carriage is a risk factor for subsequent invasive infection. We recently investigated the influence of host genetics on S. aureus carriage in Danish middle-aged and elderly twins, which indicated no significant heritability that could account for the observed S. aureus carriage. In the present study, we performed a questionnaire-based study of S. aureus colonization on the same cohort of 2,196 Danish middle-aged and elderly twins to identify specific risk factors for S. aureus nasal colonization, including analyzing the paired twins (n = 478) that were discordant for S. aureus colonization. We found associations between risk factors and S. aureus nasal colonization among middle-aged and elderly twins, including age, male gender, psoriasis, and atopic diseases. Also, present living on a farm is clearly associated with S. aureus colonization, while smoking had a borderline statistically significant protective effect.
引用
收藏
页码：1321 / 1326
页数：6
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