Role of cadmium and arsenic as endocrine disruptors in the metabolism of carbohydrates: Inserting the association into perspectives

被引:94
作者
Sabir, Shakila [1 ,2 ]
Akash, Muhammad Sajid Hamid [1 ]
Fiayyaz, Fareeha [1 ,3 ]
Saleem, Uzma [2 ]
Mehmood, Malik Hassan [2 ]
Rehman, Kanwal [4 ]
机构
[1] Govt Coll Univ Faisalabad, Dept Pharmaceut Chem, Faisalabad, Pakistan
[2] Govt Coll Univ Faisalabad, Dept Pharmacol, Faisalabad, Pakistan
[3] Govt Coll Univ Faisalabad, Dept Microbiol, Faisalabad, Pakistan
[4] Univ Agr Faisalabad, Inst Pharm Physiol & Pharm, Faisalabad, Pakistan
关键词
Glycolysis; Glucogenesis; Gluconeogenesis; Glucose homeostasis; EPINEPHRINE-INDUCED HYPERGLYCEMIA; HEPATIC GLYCOGEN-SYNTHESIS; TYPE-2; DIABETES-MELLITUS; HEAVY-METALS; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; DRINKING-WATER; EXPOSURE; METALLOTHIONEIN;
D O I
10.1016/j.biopha.2019.108802
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Endocrine disrupting chemicals (EDCs) have widespread environmental distribution originated from both natural and anthropogenic sources. From the last few decades, their contamination has been raised dramatically owing to continuous discharge in sewage and untreated industrial effluents. They have rapidly gained a considerable attention due to their critical role in the development of multiple endocrine-related disorders notably diabetes mellitus (DM). Cadmium and arsenic, among the most hazardous EDCs, are not only widely spread in our environment, but they are also found to be associated with wide range of health hazards. After entering into the human body, they are preferably accumulated in the liver, kidney and pancreas where they exhibit deleterious effects on carbohydrate metabolism pathways notably glycolysis, glucogenesis and gluconeogenesis through the modification and impairment of relevant key enzymes activity. Impairment of hepatic glucose homeostasis plays a crucial role in the pathogenesis of DM. Along with compromised function of pancreas and muscles, diminished liver and kidney functions also contribute considerably to increase the blood glucose level. These metals have potential to bring conformational changes in these enzymes and make them inactive. Additionally, these metals also disturb the hormonal balance, such as insulin, glucocorticoids and catecholamines; by damaging pancreas and adrenal gland, respectively. Moreover, these metals also enhance the production of reactive oxygen species and depress the anti-oxidative defense mechanism with subsequent disruption of multiple organs. In this article, we have briefly highlighted the impact of arsenic and cadmium on the metabolism of carbohydrates and the enzymes that are involved in carbohydrate metabolism and glucose homeostasis.
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页数:10
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共 137 条
[91]   Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis [J].
Radziuk, J ;
Pye, S .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2001, 17 (04) :250-272
[92]   Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes [J].
Rafacho, Alex ;
Ortsater, Henrik ;
Nadal, Angel ;
Quesada, Ivan .
JOURNAL OF ENDOCRINOLOGY, 2014, 223 (03) :R49-R62
[93]   Heavy metals in Australian grown and imported rice and vegetables on sale in Australia: Health hazard [J].
Rahman, M. Azizur ;
Rahman, Mohammad Mahmudur ;
Reichman, Suzie M. ;
Lim, Richard P. ;
Naidu, Ravi .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2014, 100 :53-60
[94]   CHRONIC HEPATIC AND RENAL TOXICITY BY CADMIUM IN RATS [J].
RAJANNA, B ;
HOBSON, M ;
REESE, J ;
SAMPLE, E ;
CHAPATWALA, KD .
DRUG AND CHEMICAL TOXICOLOGY, 1984, 7 (03) :229-241
[95]   INVIVO EFFECTS OF CADMIUM CHLORIDE ON CERTAIN ASPECTS OF PROTEIN-METABOLISM IN TISSUES OF A FRESH-WATER FIELD CRAB BARYTELPHUSA-GUERINI [J].
REDDY, SLN ;
VENUGOPAL, NBRK .
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1991, 46 (04) :583-590
[96]   Double-Edged Effects of Arsenic Compounds: Anticancer and Carcinogenic Effects [J].
Rehman, Kanwal ;
Naranmandura, Hua .
CURRENT DRUG METABOLISM, 2013, 14 (10) :1029-1041
[97]   Arsenic metabolism and thioarsenicals [J].
Rehman, Kanwal ;
Naranmandura, Hua .
METALLOMICS, 2012, 4 (09) :881-892
[98]   Targeting hepatic glucose metabolism in the treatment of type 2 diabetes [J].
Rines, Amy K. ;
Sharabi, Kfir ;
Tavares, Clint D. J. ;
Puigserver, Pere .
NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (11) :786-804
[99]   EFFECTS OF CADMIUM EXPOSURE ON GLYCOGEN-PHOSPHORYLASE ACTIVITY IN RAT PLACENTA AS DEMONSTRATED BY HISTOCHEMICAL MEANS [J].
ROELFZEMA, WH ;
HACKER, HJ ;
VANNOORDEN, CJF .
HISTOCHEMISTRY, 1989, 91 (04) :305-308
[100]   Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids [J].
Ronco, A. M. ;
Urrutia, M. ;
Montenegro, M. ;
Llanos, M. N. .
TOXICOLOGY LETTERS, 2009, 188 (03) :186-191