The roles of nitric oxide in murine cardiovascular development

被引：15
作者：
Nath, AK
Madri, JA
机构：
[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA
[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
来源：
DEVELOPMENTAL BIOLOGY | 2006年 / 292卷 / 01期
关键词：
nitric oxide; nitric oxide synthase; development; cardiovascular; diabetes; vasculopathy; vitelline; yolk sac;
D O I：
10.1016/j.ydbio.2005.12.039
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nitric oxide (NO) participates in a diverse array of biological functions in mammalian organ systems. Depending on the biochemical environment, the production of No may result in cytoprotection or cytotoxicity. The paradoxical actions of NO arise from the complexities generated by the redox milieu, NO concentration/bioavailability, and tissue/cell context, which ultimately result in the wide range of regulatory roles observed. Additionally, in physiological versus pathological states, NO often displays diametrically opposing affects in several organ systems. Here, we will discuss the roles of NO during reproduction, organ system development, in particular, the cardiovascular system, and its potential implications in diabetes- induced fetal defects. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：25 / 33
页数：9
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