A new screening method for flunitrazepam in vodka and tequila by fluorescence spectroscopy

被引：14

作者：

Leesakul, Nararak ^{[1
,2
]}

Pongampai, Sirintip ^{[3
]}

Kanatharana, Proespichaya ^{[1
,2
,4
]}

Sudkeaw, Pravit ^{[1
,2
]}

Tantirungrotechai, Yuthana ^{[5
,6
]}

Buranachai, Chittanon ^{[4
,7
]}

机构：

[1] Prince Songkla Univ, Dept Chem, Fac Sci, Hat Yai 90112, Songkhla, Thailand

[2] Prince Songkla Univ, Ctr Innovat Chem, Fac Sci, Hat Yai 90112, Songkhla, Thailand

[3] Prince Songkla Univ, Dept Forens Sci, Fac Sci, Hat Yai 90112, Songkhla, Thailand

[4] Prince Songkla Univ, Trace Anal & Biosensor Res Ctr, Fac Sci, Hat Yai 90112, Songkhla, Thailand

[5] Natl Sci & Technol Dev Agcy, Natl Nanotechnol Ctr, Klongluang 12120, Pathumthani, Thailand

[6] Thammasat Univ, Dept Chem, Fac Sci & Technol, Pathum Thani 12121, Thailand

[7] Prince Songkla Univ, Dept Phys, Fac Sci, Hat Yai 90112, Songkhla, Thailand

来源：

LUMINESCENCE | 2013年 / 28卷 / 01期

关键词：

flunitrazepam; rohypnol; photochemistry; protonation; PERFORMANCE; METABOLITES;

D O I：

10.1002/bio.2348

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new screening method for flunitrazepam in colourless alcoholic beverages based on a spectroscopic technique is proposed. Absorption and steady-state fluorescence of flunitrazepam and its protonated form with various acids were investigated. The redshift of the wavelength of maximum absorption was distinctively observed in protonated flunitrazepam. An emissive fluorescence at 472nm was detected in colourless spirits (vodka and tequila) at room temperature. 2-M perchloric acid was the most appropriated proton source. By using electron ionization mass spectrometry and time-dependent density functional theory calculations, the possible structure of protonated flunitrazepam was identified to be 2-nitro-N-methylacridone, an acridone derivative as opposed to 2-methylamino-5-nitro-2-fluorobenzophenone, a benzophenone derivative. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：76 / 83

页数：8

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