Enantioselective Synthesis of Axially Chiral Benzimidazoles Bearing a C-N axis via Pd-Catalyzed Buchwald-Hartwig-Amination

被引：6

作者：

Zhang, Peng ^{[1
]}

Feng, Jia ^{[1
]}

Uu, Ren-rong ^{[1
]}

机构：

[1] Qingdao Univ, Coll Chem & Chem Engn, Ningxia Rd 308, Qingdao 266071, Peoples R China

来源：

SYNLETT | 2022年 / 33卷 / 16期

关键词：

atropisomerism; palladium; amination; benzimidazole atropisomers; asymmetric catalysis; STEREOSELECTIVE-SYNTHESIS; ATROPISOMERIC ANILIDES; ARYL HALIDES; CONSTRUCTION; RESOLUTION; CHEMISTRY; ARYLATION; CHLORIDES; INDOLES; BONDS;

D O I：

10.1055/a-1833-8979

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzimidazole atropisomers bearing a C-N axis are privileged structural frameworks in pharmaceutical and natural products, thus appealing an increasing interest for its asymmetric synthesis. Here, we briefly discuss recent advances in the asymmetric synthesis of benzimidazole atropisomers with a C-N axis, with particular attention to our recently developed palladium-catalyzed intramolecular Buchwald-Hartwig amination strategy.

引用

页码：1589 / 1595

页数：7

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