Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis

被引：11
作者：
Huo, Xiaqin [1 ,2 ,3 ,4 ]
Yao, Liang [3 ,4 ]
Han, Xue [1 ]
Li, Wen [1 ,2 ]
Liu, Junjuan [1 ,2 ]
Zhou, Lijun [1 ,2 ]
Gou, Yuanfeng [1 ,2 ]
Yang, Kehu [3 ,4 ]
Liu, Huiling [1 ,2 ]
机构：
[1] Gansu Prov Peoples Hosp, Dept Gynecol & Obstet, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China
[2] Gansu Univ Tradit Chinese Med, Dept Clin Med, Lanzhou 730000, Gansu, Peoples R China
[3] Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China
[4] Gansu Prov Hosp, Inst Clin Res & Evidence Based Med, Lanzhou 730000, Gansu, Peoples R China
来源：
ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2019年 / 299卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Hysterectomy; Ovarian cancer; Risk; Meta-analysis; ORAL-CONTRACEPTIVE USE; TUBAL-LIGATION; UNILATERAL OOPHORECTOMY; AFRICAN-AMERICAN; RECOMMENDATIONS; SOCIETY; QUALITY; WOMEN;
D O I：
10.1007/s00404-018-5020-1
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
PurposeThe association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk.MethodsPubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs).ResultsA total of 18 case-control studies were included in the meta-analysis. We found that there was no statistical significance for ovarian cancer risk following hysterectomy (OR 0.97, 95% CI 0.83-1.12). And in subgroup analysis, the protective effects were observed for invasive endometrioid/clear cell carcinomas after hysterectomy (OR 0.70, 95% CI 0.51, 0.94; I-2=0%), and no statistical significance for serous and mucinous.ConclusionsHysterectomy showed no relationship with ovarian cancer. But a reduced risk was found for endometrioid-invasive OC. These findings could provide evidence for patients with benign gynecological disease and clinicians to make appropriate decision about whether to conduct hysterectomy.
引用
收藏
页码：599 / 607
页数：9
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