Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization

被引:31
作者
Bilousova, Tina [1 ]
Dang, Hoa [1 ]
Xu, Willem [1 ]
Gustafson, Sarah [1 ]
Jin, Yingli [1 ]
Wickramasinghe, Lalinda [1 ]
Won, Tony [1 ]
Bobarnac, Gabriela [1 ]
Middleton, Blake [1 ]
Tian, Jide [1 ]
Kaufman, Daniel L. [1 ]
机构
[1] Univ Calif Los Angeles, UCLA Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
关键词
Major histocompatibility complex class I; Neurodevelopment; MHCI-deficient; Neurite; Free heavy chain; Axon; Soluble MHC; MHC CLASS-I; INSULIN-RECEPTORS; HEAVY-CHAINS; HIPPOCAMPAL-NEURONS; CELL-SURFACE; SYNAPTIC PLASTICITY; CIS-INTERACTIONS; T-CELLS; ANTIGENS; BETA-2-MICROGLOBULIN;
D O I
10.1016/j.jneuroim.2012.03.008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We studied cultured hippocampal neurons from embryonic wildtype, major histocompatibility complex class I (MHCI) heavy chain-deficient ((KDb)-D-b-/-) and NSE-D-b (which have elevated neuronal MHCI expression) C57BL/6 mice. (KDb)-D-b-/- neurons displayed slower neuritogenesis and establishment of polarity, while NSE-D-b neurons had faster neurite outgrowth, more primary neurites, and tended to have accelerated polarization. Additional studies with beta 2M-/- neurons, exogenous beta 2M, and a self-MHCI monomer suggest that free heavy chain cis interactions with other surface molecules can promote neuritogenesis while tripartite MHCI interactions with classical MHCI receptors can inhibit axon outgrowth. Together with the results of others, MHCI appears to differentially modulate neuritogenesis and synaptogenesis. (c) 2012 Elsevier B.V. All rights reserved.
引用
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页码:1 / 8
页数:8
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