Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease

被引：331

作者：

Gelders, Geraldine ^{[1
]}

Baekelandt, Veerle ^{[1
]}

Van der Perren, Anke ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Neurosci, Lab Neurobiol & Gene Therapy, Leuven, Belgium

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2018年 / 2018卷

关键词：

REPEAT KINASE 2; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; VENTRICULAR CEREBROSPINAL-FLUID; INHIBITS MICROGLIAL ACTIVATION; ALPHA-SYNUCLEIN STRAINS; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; LEWY BODY DISORDERS; SUBSTANTIA-NIGRA; MOUSE MODEL;

D O I：

10.1155/2018/4784268

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases. Nevertheless, several questions remain unanswered regarding the role of misfolded protein aggregates and the cause of neuronal cell death. Recently, it has been postulated that neuroinflammatory processes might play a crucial role in the pathogenesis of PD. Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration. Whether these inflammatory processes are directly involved in the etiology of PD or represent secondary consequences of nigrostriatal pathway injury is the subject of intensive research. Immune alterations in response to extracellular a-synuclein may play a critical role in modulating Parkinson's disease progression. In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration.

引用

页数：12

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