Prognostic value of liver dysfunction assessed by MELD-XI scoring system in patients undergoing transcatheter aortic valve implantation

Background: There are limited data regarding the influence of liver dysfunction on outcomes of transcatheter aortic valve implantation (TAVI). Model for End-stage Liver Disease eXcluding International normalized ratio (MELD-XI) score, which was originally developed for patients with cirrhosis awaiting liver transplantation, has been reported as a predictor of heart disease. The aim of this study was to investigate the prognostic value of MELD-XI score for patients undergoing TAVI. Methods: Data from the prospectively maintained Optimized transCathEter vAlvular iNtervention (OCEAN-TAVI) multicenter registry were collected in 749 patients who underwent TAVI between October 2013 and August 2015. MELD-XI score was calculated as follows: 11.76 x Ln (creatinine)+ 5.11 x Ln (total bilirubin)+ 9.44. Patients were categorized based on MELD-XI score N 10 or <= 10, and compared with regard to clinical characteristics and outcomes of TAVI. Results: Higher MELD-XI score was associated with lower 30-day survival (95.6% vs 98.5%, P = 0.03). Kaplan-Meier analysis revealed that higher MELD-XI score also was associated with lower 6-month survival (P < 0.01). Multivariate Cox regression analysis showed that MELD-XI score was an independent predictor of 6-month cumulative mortality. Receiver operating characteristic analysis revealed that MELD-XI score showed better accuracy in predicting 6-month mortality compared with Logistic European System for Cardiac Operative Risk Evaluation, European System for Cardiac Operative Risk Evaluation II, and Society of Thoracic Surgeons scores (area under the curve - 0.67, 0.58, 0.57, and 0.60, respectively). Conclusion: Evaluation of liver dysfunction according to MELD-XI score provides additional risk information for patients undergoing TAVI. (C) 2016 Elsevier Ireland Ltd. All rights reserved.