Synthesis and Characterization of Reinforced Poly(ethylene glycol)/Chitosan Hydrogel as Wound Dressing Materials

被引：34
作者：
Chen, Szu-Hsien [1 ]
Tsao, Ching-Ting [1 ,2 ]
Chang, Chih-Hao [3 ,4 ]
Lai, Yi-Ting [5 ]
Wu, Ming-Fung [6 ]
Liu, Zheng-Wei [1 ]
Chuang, Ching-Nan [1 ]
Chou, Hung-Chia [5 ]
Wang, Chih-Kuang [7 ]
Hsieh, Kuo-Haung [1 ]
机构：
[1] Natl Taiwan Univ, Coll Engn, Inst Polymer Sci & Engn, Taipei 10617, Taiwan
[2] Chang Gung Univ, Dept Anat, Epithelial Biol Lab, Transgen Mice Core Lab, Tao Yuan 33302, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Orthoped, Taipei 10018, Taiwan
[4] Natl Taiwan Univ Coll Med, Taipei 10018, Taiwan
[5] Natl Taiwan Univ, Coll Engn, Dept Chem Engn, Taipei 10617, Taiwan
[6] Natl Taiwan Univ, Coll Med, Anim Med Ctr, Taipei 10018, Taiwan
[7] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 80708, Taiwan
来源：
MACROMOLECULAR MATERIALS AND ENGINEERING | 2013年 / 298卷 / 04期
关键词：
chitosan; hydrogels; mechanical strength; PEG; wound dressing; BIODEGRADABLE POLYMER; CHITOSAN; ACID; CONSTRUCTION; REGENERATION; COMPOSITE; OUTGROWTH; STRENGTH;
D O I：
10.1002/mame.201200054
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
PEG is used to reinforce chitosan-based hydrogels through the formation of ester and amide linkages. The reinforced PEG/chitosan (RPC) hydrogels exhibit significant enhancements in tensile modulus and elongation compared with neat chitosan. Other properties are thoroughly investigated and indicate that the physicochemical and in vitro degradation properties of the RPC hydrogels depend on the amount and molecular weight of the PEG. The RPC hydrogels can control evaporative water loss at a suitable rate to maintain a moist environment. In terms of in vitro biological properties, 3T3 fibroblasts show good viability with the RPC hydrogels, which indicates that the RPC hydrogels may be used as wound dressing materials.
引用
收藏
页码：429 / 438
页数：10
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