Choline Chloride/Urea as an Eco-Friendly Deep Eutectic Solvent for TCT-Mediated Amide Coupling at Room Temperature

被引：11

作者：

Salimiyan, Kimiya ^{[1
]}

Saberi, Dariush ^{[2
,3
]}

机构：

[1] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran

[2] Persian Gulf Univ, Marine Chem Dept, Fac Marine Sci & Technol, Bushehr 75169, Iran

[3] Persian Gulf Univ, Fisheries & Aquaculture Dept, Fac Agr & Nat Resources, Bushehr 75169, Iran

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 14期

关键词：

Deep eutectic solvent; Choline chloride; Amide bond formation; Cyanuric chloride; Green solvent; CARBOXYLIC-ACIDS; BOND FORMATION; IONIC LIQUIDS; 2,4,6-TRICHLORO-1,3,5-TRIAZINE TCT; OXIDATIVE AMIDATION; CYANURIC CHLORIDE; ACTIVATION; ALDEHYDES; PHENOLS; REAGENT;

D O I：

10.1002/slct.201804066

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A desirable alternative to organic solvents, very cheap, non-toxic and biodegradable deep eutectic solvent (DES) based on choline chloride and urea was introduced for 2,4,6-trichloro triazine mediated amide bond formation between carboxylic acids and amines at room temperature. Sub-stoichiometric amount of TCT was used as a cheap and readily available C-O activating reagent. Various derivatives of amines were coupled with carboxylic acids, via triacylated triazine intermediate, resulting the reaction of acids with TCT, and the corresponding amides were obtained in moderate to good yields.

引用

页码：3985 / 3989

页数：5

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