Tobramycin-impregnated calcium sulfate pellets for the treatment of chronic osteomyelitis in children and adolescents

被引：31

作者：

Andreacchio, Antonio ^{[1
]}

Alberghina, Flavia ^{[1
]}

Paonessa, Matteo ^{[1
]}

Cravino, Mattia ^{[1
]}

De Rosa, Vincenzo ^{[2
]}

Canavese, Federico ^{[3
]}

机构：

[1] Regina Margherita Childrens Hosp, Dept Pediat Orthoped Surg, Turin, Italy

[2] Bellinzona & Valli Reg Hosp, Dept Pediat Orthoped, Bellinzona, Switzerland

[3] Univ Hosp Estaing, Dept Pediat Surg, 1 Pl Lucie & Raymond Aubrac, F-63003 Clermont Ferrand, France

来源：

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B | 2019年 / 28卷 / 03期

关键词：

adolescents; calcium sulfate pellets; children; chronic osteomyelitis; single-stage surgery; BONE DEFECTS; SUBSTITUTE; MANAGEMENT; INFECTION;

D O I：

10.1097/BPB.0000000000000517

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The aim of this work was to evaluate the outcome and efficacy of treatment in a homogeneous group of skeletally immature patients with chronic osteomyelitis of the long bones managed by a combination of radical debridement and insertion of tobramycin-impregnated calcium sulfate pellets to fill the bone defect in a single-stage procedure. Between 2011 and 2016, 12 skeletally immature patients were treated surgically by the reported technique. Single-stage surgery using tobramycin-impregnated calcium sulfate pellets in association with systemic antibiotic therapy yields satisfactory outcomes in skeletally immature children presenting chronic osteomyelitis by reducing the risk of occurrence of comorbidities, hospital stays, and healthcare costs.

引用

页码：189 / 195

页数：7

共 30 条

[21] Paley D, 2000, J ORTHOP TRAUMA, V16, P723
[22] Effect of Various Concentrations of Antibiotics on Osteogenic Cell Viability and Activity
Rathbone, Christopher R.
Cross, Jessica D.
Brown, Kate V.
Murray, Clinton K.
Wenke, Joseph C.
[J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 2011, 29 (07) : 1070 - 1074
[23] Aminoglycosides versus bacteria - a description of the action, resistance mechanism, and nosocomial battleground
Shakil, Shazi
Khan, Rosina
Zarrilli, Raffaele
Khan, Asad U.
[J]. JOURNAL OF BIOMEDICAL SCIENCE, 2008, 15 (01) : 5 - 14
[24] Tsai Yao-Hung, 2004, Chang Gung Med J, V27, P542
[25] Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets
Turner, TM
Urban, RM
Hall, DJ
Chye, PC
Segreti, J
Gitelis, S
[J]. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2005, (437) : 97 - 104
[26] Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review
van Gestel, N. A. P.
Geurts, J.
Hulsen, D. J. W.
van Rietbergen, B.
Hofmann, S.
Arts, J. J.
[J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
[27] Minimizing the surgical approach in patients with spondylitis
von Stechow, D
Scale, D
Rauschmann, MA
[J]. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2005, (439) : 61 - 67
[28] Systemic exposure to tobramycin after local antibiotic treatment with calcium sulphate as carrier material
Wahl, Peter
Livio, Francoise
Jacobi, Matthias
Gautier, Emanuel
Buclin, Thierry
[J]. ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 2011, 131 (05) : 657 - 662
[29] Osteomyelitis treated with gentamicin-PMMA beads - 100 patients followed for 1-12 years
Walenkamp, GHIM
Kleijn, LLA
de Leeuw, M
[J]. ACTA ORTHOPAEDICA SCANDINAVICA, 1998, 69 (05): : 518 - 522
[30] Local antibiotic therapy in the treatment of open fractures and osteomyelitis
Zalavras, CG
Patzakis, MJ
Holtom, P
[J]. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2004, (427) : 86 - 93

← 1 2 3 →