Tobramycin-impregnated calcium sulfate pellets for the treatment of chronic osteomyelitis in children and adolescents

被引：31

作者：

Andreacchio, Antonio ^{[1
]}

Alberghina, Flavia ^{[1
]}

Paonessa, Matteo ^{[1
]}

Cravino, Mattia ^{[1
]}

De Rosa, Vincenzo ^{[2
]}

Canavese, Federico ^{[3
]}

机构：

[1] Regina Margherita Childrens Hosp, Dept Pediat Orthoped Surg, Turin, Italy

[2] Bellinzona & Valli Reg Hosp, Dept Pediat Orthoped, Bellinzona, Switzerland

[3] Univ Hosp Estaing, Dept Pediat Surg, 1 Pl Lucie & Raymond Aubrac, F-63003 Clermont Ferrand, France

来源：

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B | 2019年 / 28卷 / 03期

关键词：

adolescents; calcium sulfate pellets; children; chronic osteomyelitis; single-stage surgery; BONE DEFECTS; SUBSTITUTE; MANAGEMENT; INFECTION;

D O I：

10.1097/BPB.0000000000000517

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The aim of this work was to evaluate the outcome and efficacy of treatment in a homogeneous group of skeletally immature patients with chronic osteomyelitis of the long bones managed by a combination of radical debridement and insertion of tobramycin-impregnated calcium sulfate pellets to fill the bone defect in a single-stage procedure. Between 2011 and 2016, 12 skeletally immature patients were treated surgically by the reported technique. Single-stage surgery using tobramycin-impregnated calcium sulfate pellets in association with systemic antibiotic therapy yields satisfactory outcomes in skeletally immature children presenting chronic osteomyelitis by reducing the risk of occurrence of comorbidities, hospital stays, and healthcare costs.

引用

页码：189 / 195

页数：7

共 30 条

[1] Chronic Osteomyelitis in Children: Treatment by Intramedullary Reaming and Antibiotic-impregnated Cement Rods
Bar-On, Elhanan
Weigl, Daniel M.
Bor, Noam
Becker, Tali
Katz, Kalman
Mercado, Eyal
Livni, Gilat
[J]. JOURNAL OF PEDIATRIC ORTHOPAEDICS, 2010, 30 (05) : 508 - 513
[2] Effectiveness of local antibiotic delivery with an osteoinductive and osteoconductive bone-graft substitute
Beardmore, AA
Brooks, DE
Wenke, JC
Thomas, DB
[J]. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2005, 87A (01) : 107 - 112
[3] Calcium Sulfates: What Is the Evidence?
Beuerlein, Murray J. S.
Mckee, Michael D.
[J]. JOURNAL OF ORTHOPAEDIC TRAUMA, 2010, 24 : S46 - S51
[4] Canavese F, 2016, EUR J ORTHOP SURG TR, V27, P221
[5] Chang W, 2007, ACTA ORTHOP BELG, V73, P238
[6] Cho Se-Hyun, 1997, Bulletin Hospital for Joint Diseases, V56, P140
[7] Osteomyelitis and septic arthritis in children: current concepts
Dodwell, Emily R.
[J]. CURRENT OPINION IN PEDIATRICS, 2013, 25 (01) : 58 - 63
[8] The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis A SERIES OF 195 CASES
Ferguson, J. Y.
Dudareva, M.
Riley, N. D.
Stubbs, D.
Atkins, B. L.
McNally, M. A.
[J]. BONE & JOINT JOURNAL, 2014, 96B (06) : 829 - 836
[9] The Impact of the Current Epidemiology of Pediatric Musculoskeletal Infection on Evaluation and Treatment Guidelines
Gafur, Omar A.
Copley, Lawson A. B.
Hollmig, S. Tyler
Browne, Richard H.
Thornton, Lori A.
Crawford, Shellye E.
[J]. JOURNAL OF PEDIATRIC ORTHOPAEDICS, 2008, 28 (07) : 777 - 785
[10] Gitelis Steven, 2002, J Orthop Surg (Hong Kong), V10, P53

← 1 2 3 →