The cellular function of srGAP3 and its role in neuronal morphogenesis

被引：31
作者：
Bacon, Claire [1 ]
Endris, Volker [1 ]
Rappold, Gudrun A. [1 ]
机构：
[1] Heidelberg Univ, Dept Human Mol Genet, D-69120 Heidelberg, Germany
来源：
MECHANISMS OF DEVELOPMENT | 2013年 / 130卷 / 6-8期
关键词：
Slit-Robo GAPs; Rho GTPases; Lamellipodin; WAVE1; Actin dynamics; Dendritic spines; LINKED MENTAL-RETARDATION; F-BAR DOMAIN; RHO GTPASES; MEMBRANE PROTRUSIONS; AXON GUIDANCE; SLIT; MIGRATION; PROTEIN; DYNAMICS; WAVE-1;
D O I：
10.1016/j.mod.2012.10.005
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Slit-Robo GTPase activating protein 3 (srGAP3) dynamically regulates cytoskeletal reorganisation through inhibition of the Rho GTPase Rac1 and interaction with actin remodelling proteins. SrGAP3-mediated reorganisation of the actin cytoskeleton is crucial for the normal development of dendritic spines and loss of srGAP3 leads to abnormal synaptic activity and impaired cognitive behaviours in mice, which is reminiscent of an association between disrupted srGAP3 and intellectual disability in humans. Additionally, srGAP3 has been implicated to act downstream of Slit-Robo signalling in commissural axons of the spinal cord. Thus, srGAP3-mediated cytoskeletal reorganisation has an important influence on a variety of neurodevelopmental processes, which may be required for normal cognitive function. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：391 / 395
页数：5
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