Senescence and NFκB A Trojan horse in tumors?

被引：5

作者：

Crescenzi, Elvira ^{[1
]}

De Palma, Raffaele ^{[2
]}

Leonardi, Antonio ^{[3
]}

机构：

[1] Ist Endocrinol & Oncol Sperimentale, Naples, Italy

[2] Univ Naples 2, Dipartimento Med Chirurg Internist Clin & Sperime, Naples, Italy

[3] Univ Naples Federico II, Dipartimento Biol & Patol Cellulare & Mol, Naples, Italy

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 09期

关键词：

NF kappa B; immune response; senescence; Fas; SASP; FAS-MEDIATED APOPTOSIS; NECROSIS-FACTOR-ALPHA; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; DNA-DAMAGE; IN-VIVO; CELLS; ACTIVATION; P53; RESTORATION;

D O I：

10.4161/onci.22525

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The induction of senescence in tumor cells impairs transformation and promotes an anticancer immune response resulting from the production by senescent cells of cytokines and chemokines, an aspect known as "senescence-associated secretory phenotype" (SASP). Here we discuss recent findings regarding the role of NF kappa B in the modulation of the SASP and the consequent anticancer immune response.

引用

页码：1594 / 1597

页数：4

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