Data fusion in metabolomic cancer diagnostics

被引：38

作者：

Bro, Rasmus ^{[1
]}

Nielsen, Hans Jorgen ^{[2
]}

Savorani, Francesco ^{[1
]}

Kjeldahl, Karin ^{[1
]}

Christensen, Ib Jarle ^{[3
,4
]}

Brunner, Nils ^{[5
]}

Lawaetz, Anders Juul ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Food Sci, DK-1958 Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Dept Surg Gastroenterol, Hvidovre, Denmark

[3] Rigshosp, Finsen Lab, Copenhagen Bioctr, DK-2100 Copenhagen, Denmark

[4] Univ Copenhagen, BRIC, DK-1958 Copenhagen, Denmark

[5] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, DK-1870 Copenhagen, Denmark

来源：

METABOLOMICS | 2013年 / 9卷 / 01期

关键词：

Biomarker; Chemometrics; Multivariate; Fingerprinting; PRIMARY COLORECTAL-CANCER; FLUORESCENCE TOPOGRAPHY; PLASMA; SPECTROSCOPY; BIOLOGY; TIMP-1; SERUM;

D O I：

10.1007/s11306-012-0446-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have recently shown that fluorescence spectroscopy of plasma samples has promising abilities regarding early detection of colorectal cancer. In the present paper, these results were further developed by combining fluorescence with the biomarkers, CEA and TIMP-1 and traditional metabolomic measurements in the form of H-1 NMR spectroscopy. The results indicate that using an extensive profile established by combining such measurements together with the biomarkers is better than using single markers.

引用

页码：3 / 8

页数：6

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