Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

被引：48

作者：

Zhang, HJ ^{[1
]}

Lu, ZZ ^{[1
]}

Tan, GT ^{[1
]}

Qiu, SX ^{[1
]}

Farnsworth, NR ^{[1
]}

Pezzuto, JM ^{[1
]}

Fong, HHS ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期

关键词：

Panax ginseng; Araliaceae; polyacetyleneginsenoside; HIV;

D O I：

10.1016/S0040-4039(01)02310-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf. -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including ID and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type I (HIV-1) with an IC50 value of 13.4 mug/mL (11.1 muM). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：973 / 977

页数：5

共 50 条

[41] A new minor triterpene saponin from kaixin-san prescription [J].

Liu, JY ;

Xiao, SY ;

Shang, WF ;

Xu, LZ ;

Yang, SL .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (04) :643-648

[42] Triterpenoid saponin from Panax ginseng increases the sensitivity of methicillin-resistant Staphylococcus aureus to β-lactam and aminoglycoside antibiotics [J].

Tsutamoto, Sakura ;

Iwasaki, Yuina ;

Shinohara, Akari ;

Imamiya, Risa ;

Samukawa, Keiichi ;

Kawada-Matsuo, Miki ;

Komatsuzawa, Hitoshi ;

Yamada, Yui ;

Mandokoro, Kouki ;

Iwao, Hiroshi ;

Horiguchi, Yasuhiko ;

Osada-Oka, Mayuko .

MICROBIOLOGY SPECTRUM, 2024, 12 (06)

[43] Saponin production by hairy root cultures of Panax ginseng CA Meyer: Influence of PGR and polyamines [J].

Hwang S.J. ;

Kim K.S. ;

Pyo B.S. ;

Hwang B. .

Biotechnology and Bioprocess Engineering, 1999, 4 (4) :309-312

[44] Mycotoxins from Alternaria Panax, the specific plant pathogen of Panax ginseng [J].

Chen, Huiqing ;

Liu, Jianzi ;

Hu, Ling ;

Yang, Jian ;

Wang, Yanduo ;

Sun, Wensong ;

Wang, Rong ;

Ding, Gang ;

Li, Yong .

MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY, 2023, 14 (04) :381-392

[45] In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria [J].

Lee, BH ;

Lee, SJ ;

Hui, JH ;

Lee, S ;

Sung, JH ;

Huh, JD ;

Moon, CK .

PLANTA MEDICA, 1998, 64 (06) :500-503

[46] A new compound from the leaves of Panax ginseng [J].

Wu, L. J. ;

Wang, L. -B. ;

Gao, H. -Y. ;

Wu, B. ;

Song, X-M. ;

Tang, Z. -S. .

FITOTERAPIA, 2007, 78 (7-8) :556-560

[47] Ginsenoside Rf2, a new dammarane glycoside from Korean red ginseng (Panax ginseng) [J].

Park, JD ;

Lee, YH ;

Kim, SI .

ARCHIVES OF PHARMACAL RESEARCH, 1998, 21 (05) :615-617

[48] Novel polyacetylene derivatives and their inhibitory activities on acetylcholinesterase obtained from Panax ginseng roots [J].

Murata, Kazuya ;

Iida, Daiki ;

Ueno, Yoshihiro ;

Samukawa, Keiichi ;

Ishizaka, Toshihiko ;

Kotake, Takeshi ;

Matsuda, Hideaki .

JOURNAL OF NATURAL MEDICINES, 2017, 71 (01) :114-122

[49] Surface-Active Properties of Solvent-Extracted Panax ginseng Saponin-Based Surfactants [J].

Mesgarzadeh, Iraj ;

Akbarzadeh, Ali Reza ;

Rahimi, Rahmatollah .

JOURNAL OF SURFACTANTS AND DETERGENTS, 2017, 20 (03) :609-614

[50] Oleanolic Triterpene Saponins from the Roots of Panax bipinnatifidus [J].

Nguyen Huu Tung ;

Tran Hong Quang ;

Nguyen Thi Thanh Ngan ;

Chau Van Minh ;

Bui Kim Anh ;

Pham Quoc Long ;

Nguyen Manh Cuong ;

Kim, Young Ho .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (11) :1417-1420

← 1 2 3 4 5 →