Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

被引：48

作者：

Zhang, HJ ^{[1
]}

Lu, ZZ ^{[1
]}

Tan, GT ^{[1
]}

Qiu, SX ^{[1
]}

Farnsworth, NR ^{[1
]}

Pezzuto, JM ^{[1
]}

Fong, HHS ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期

关键词：

Panax ginseng; Araliaceae; polyacetyleneginsenoside; HIV;

D O I：

10.1016/S0040-4039(01)02310-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf. -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including ID and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type I (HIV-1) with an IC50 value of 13.4 mug/mL (11.1 muM). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：973 / 977

页数：5

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