Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

被引：46
作者：
Zhang, HJ [1 ]
Lu, ZZ [1 ]
Tan, GT [1 ]
Qiu, SX [1 ]
Farnsworth, NR [1 ]
Pezzuto, JM [1 ]
Fong, HHS [1 ]
机构：
[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期
关键词：
Panax ginseng; Araliaceae; polyacetyleneginsenoside; HIV;
D O I：
10.1016/S0040-4039(01)02310-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf. -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including ID and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type I (HIV-1) with an IC50 value of 13.4 mug/mL (11.1 muM). (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：973 / 977
页数：5
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