Comparison of the Efficacy of HYAFF11 Mesh with Collagen Membranes in Guided Bone Regeneration

This study aimed to evaluate the efficacy of HYAFF11-based meshes in guided bone regenera-tion (GBR). Two defects of 5-mm width were prepared in the calvaria of 36 rats. The rats were divided into the following groups: empty defect (group E); HYAFF11-based mesh (group HY), colla-gen membrane (group CM), xenograft (group X), xenograft + HYAFF11 mesh (group X+ HY), and xenograft +collagen membrane (group X+CM). Sacrifications were performed at the third and sixth post-surgical weeks, followed by histological evaluation. The highest amount of new bone (NB) for-mation in the third week was observed in group X+CM (0.94+0.40 mm2), followed by group X+HY (0.80+ 0.21 mm2). The highest amount of NB formation in the sixth week was observed in group X + CM (1.57+ 0.66 mm2), followed by groups X and X + HY (1.39+ 0.48 mm2 and 1.34+0.44 mm2, respectively). There was no statistically significant difference in the amount of residual graft between groups X+HY, X+CM, and X at the third and sixth weeks. Considering the close values observed between the groups, it could be concluded that HYAFF11 may be an alternative biomate-rial for use in GBR. Further studies using different graft materials and defect sizes are required to evaluate the effectiveness of HYAFF11 in GBR.