Normal Tension Glaucoma

被引:0
作者
Prokosch, Verena [1 ,2 ]
Zwingelberg, Sarah Barbara [3 ,4 ,5 ]
Mercieca, Karl [6 ]
机构
[1] Univ Cologne, Glaukom, Cologne, Germany
[2] Uniklin Koln, Cologne, Germany
[3] Manchester Royal Eye Hosp MREH, Manchester, Lancs, England
[4] Univ Manchester, Augenheilkunde, Manchester, Lancs, England
[5] Univ Klinikums Bonn UKB, Augenklin, Bonn, Germany
[6] Univ Klinikum Koln, Augenheilkunde, Cologne, Germany
关键词
normal tension glaucoma; neurodegenerative disease; circulatory disorder; opticus neuropathy; OPEN-ANGLE GLAUCOMA; OPTICAL COHERENCE TOMOGRAPHY; LAYER THICKNESS MEASUREMENTS; CENTRAL CORNEAL THICKNESS; INTRAOCULAR-PRESSURE; POPULATION; PREVALENCE; PROGRESSION; HISTORY;
D O I
10.1055/a-1758-3486
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Normal tension glaucoma (NTG) is a subvariant of primary open angle glaucoma (POAG) or a separate entity. NTG is defined as chronic open angle glaucoma without elevated intraocular pressure or normal intraocular pressure. Normal intraocular pressure is between 10 and 21 mm Hg and is defined as two times the standard deviation of the mean intraocular pressure in the normal population. In addition to the absence of elevated intraocular pressure, all the classic symptoms of glaucoma are otherwise present. These include a conspicuous glaucomatous optic disc excavation, nerve fibre bundle defects, and corresponding visual field defects. Papillary rim haemorrhages are frequently found. The visual field defects in NDG are usually more central compared to POAG and are therefore described as more disturbing by the patient. The anterior chamber angle is open and there are no other changes suggestive of secondary glaucoma (pigment dispersion, pseudo-exfoliation). The exact pathophysiology of NDG is not well understood. Pathophysiologically, circulatory disturbances in the sense of arterial hypo- as well as hypertension may play an essential role or at least increase the susceptibility of the optic nerve to intraocular pressure fluctuations as well as blood pressure dips. Therefore, this requires not only a purely ophthalmologic but also interdisciplinary treatment of the patient with confirmed NDG. The primary goal of treatment is the reduction of intraocular pressure, which can stop the disease. This article gives an overview of epidemiology, aetiology, clinical findings and therapies.
引用
收藏
页数:12
相关论文
共 44 条
[1]   Comparison of dynamic contour tonometry and Goldmann applanation tonometry in glaucoma patients and healthy subjects [J].
Barleon, Lorenz ;
Hoffmann, Esther M. ;
Berres, Manfred ;
Pfeiffer, Norbert ;
Grus, Franz H. .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2006, 142 (04) :583-590
[2]   Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography [J].
Blumenthal, EZ ;
Williams, JM ;
Weinreb, RN ;
Girkin, CA ;
Berry, CC ;
Zangwill, LM .
OPHTHALMOLOGY, 2000, 107 (12) :2278-2282
[3]   Prevalence of glaucoma and intraocular pressure distribution in a defined population -: The Egna-Neumarkt study [J].
Bonomi, L ;
Marchini, G ;
Marraffa, M ;
Bernardi, P ;
De Franco, I ;
Perfetti, S ;
Varotto, A ;
Tenna, V .
OPHTHALMOLOGY, 1998, 105 (02) :209-215
[4]   Medical versus surgical interventions for open angle glaucoma [J].
Burr, J ;
Azuara-Blanco, A ;
Avenell, A .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2005, (02)
[5]   Intraocular pressure fluctuation - A risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study [J].
Caprioli, Joseph ;
Coleman, Anne L. .
OPHTHALMOLOGY, 2008, 115 (07) :1123-1129
[6]   Canadian glaucoma study - 2. Risk factors for the progression of open-angle glaucoma [J].
Chauhan, Balwantray C. ;
Mikelberg, Frederick S. ;
Balaszi, A. Gordon ;
LeBlanc, Raymond P. ;
Lesk, Mark R. ;
Trope, Graham E. .
ARCHIVES OF OPHTHALMOLOGY, 2008, 126 (08) :1030-1036
[7]   Population-based glaucoma prevalence studies in Asians [J].
Cho, Hyun-Kyung ;
Kee, Changwon .
SURVEY OF OPHTHALMOLOGY, 2014, 59 (04) :434-447
[8]   Natural History of Normal-Tension Glaucoma with (Very) Low Intraocular Pressure [J].
De Moraes, Carlos Gustavo .
OPHTHALMOLOGY, 2019, 126 (08) :1117-1118
[9]  
DIELEMANS I, 1994, OPHTHALMOLOGY, V101, P1851
[10]  
Dietlein TS, 2005, OPHTHALMOLOGE, V102, P502, DOI 10.1007/s00347-004-1134-x