Interferon γ in patients with HIV/AIDS and suspicion or latent tuberculosis infection

被引：6

作者：

Garcia-Elorriaga, Guadalupe ^{[1
]}

Martinez-Velazquez, Mayte ^{[2
]}

Gaona-Flores, Veronica ^{[2
]}

del Rey-Pineda, Guillermo ^{[3
]}

Gonzalez-Bonilla, Cesar ^{[1
]}

机构：

[1] CMNR, Immunol & Infectol Res Unit, IMSS, Mexico City 02990, DF, Mexico

[2] CMNR, Hop Infectol, IMSS, Mexico City 02990, DF, Mexico

[3] Hosp Infantil Mexico Dr Federico Gomez, CMNR, Banco Cent Sangre, Dpto Infectol, Mexico City, DF, Mexico

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2013年 / 6卷 / 02期

关键词：

AIDS; HIV; IGRA; Interferon gamma; Latent tuberculosis infection; SKIN-TEST; DIAGNOSIS; ASSAYS;

D O I：

10.1016/S1995-7645(13)60009-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To assess the usefulness of IGRA test (QuantiFERON (R) -Cell mediated immune) compared with the tuberculin skin test. Methods: A cross sectional study was carried out in Mexico, 25 infected patients with HIV-AIDS and the suspicion or with latent tuberculous infection (LTBI) who were >18 years of age and without treatment for tuberculosis (TB), were enrolled in the study. Results: Median cluster of differentiation (CD4) count was 364 cells/ mu L and median HIV viral load was 50 copies/mL. Overall, 20 patients (80%) had at least one positive diagnostic test for LTBI: four (16%) had a positive tuberculin skin test and 19 (76%), a positive QuantiFERON (R) -tuberculosis. Conclusions: No agreement is found between the two diagnostic tests: k = -0.004, 95% confidence interval (-0.2219, 0.2210). Additional longitudinal studies among HIV-infected populations with high prevalence of TB are needed to further assess the usefulness of IGRAs in this patient population.

引用

页码：135 / 138

页数：4

共 22 条

[1]

[Anonymous], 2002, GLOBAL TUBERCULOSIS

[2]

[Anonymous], EPIDEMIA DEL SIDA

[3] Update on the treatment of tuberculosis and latent tuberculosis infection [J].

Blumberg, HM ;

Leonard, MK ;

Jasmer, RM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (22) :2776-2784

[4] Latent tuberculosis in HIV positive, diagnosed by the M-tuberculosis specific interferon-γ test [J].

Brock, Inger ;

Ruhwald, Morten ;

Lundgren, Bettina ;

Westh, Henrik ;

Mathiesen, Lars R. ;

Ravn, Pernille .

RESPIRATORY RESEARCH, 2006, 7 (1)

[5] INSTABILITY OF DELAYED-TYPE HYPERSENSITIVITY SKIN-TEST ANERGY IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].

CAIAFFA, WT ;

GRAHAM, NMH ;

GALAI, N ;

RIZZO, RT ;

NELSON, KE ;

VLAHOV, D .

ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (19) :2111-2117

[6] Current medical treatment for tuberculosis [J].

Chan, ED ;

Iseman, MD .

BMJ-BRITISH MEDICAL JOURNAL, 2002, 325 (7375) :1282-1286

[7] Tuberculin skin testing in patients with HIV infection: Limited benefit of reduced cutoff values [J].

Cobelens, Frank G. ;

Egwaga, Saidi M. ;

van Ginkel, Tessa ;

Muwinge, Hemed ;

Matee, Mecky I. ;

Borgdorff, Martien W. .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (05) :634-639

[8]

de Albuquerque M de F, 2001, Rev Soc Bras Med Trop, V34, P369, DOI 10.1590/S0037-86822001000400010

[9] TUBERCULIN SENSITIVITY AND HIV-1 STATUS OF PATIENTS ATTENDING A SEXUALLY-TRANSMITTED DISEASES CLINIC IN LUSAKA, ZAMBIA - A CROSS-SECTIONAL STUDY [J].

DUNCAN, LE ;

ELLIOTT, AM ;

HAYES, RJ ;

HIRA, SK ;

TEMBO, G ;

MUMBA, GT ;

EBRAHIM, SH ;

QUIGLEY, M ;

POBEE, JO ;

MCADAM, PWJ .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1995, 89 (01) :37-40

[10] Tuberculosis [J].

Frieden, TR ;

Sterling, TR ;

Munsiff, SS ;

Watt, CJ ;

Dye, C .

LANCET, 2003, 362 (9387) :887-899

← 1 2 3 →