Recent advances in the neurobiology and neuropharmacology of Alzheimer's disease

被引：113
作者：
Kumar, Kushal [1 ,2 ]
Kumar, Ashwani [1 ]
Keegan, Richard M. [3 ]
Deshmukh, Rahul [1 ]
机构：
[1] ISF Coll Pharm, Dept Pharmacol, Neuropharmacol Div, Moga 142001, Punjab, India
[2] Def Inst High Altitude Res, 56 APO, Leh Ladakh 901205, India
[3] SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 98卷
关键词：
Alzheimer's disease; Amyloid plaques; Neurofibrillary tangles; Acetylcholine; New therapeutic strategies; NICOTINIC ACETYLCHOLINE-RECEPTOR; AMYLOID PRECURSOR PROTEIN; 5-HT6; RECEPTOR; BIOCHEMICAL-ABNORMALITIES; MITOCHONDRIAL DYSFUNCTION; COGNITIVE IMPAIRMENT; EMISSION-TOMOGRAPHY; VASCULAR DEMENTIA; OXIDATIVE STRESS; DNA METHYLATION;
D O I：
10.1016/j.biopha.2017.12.053
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive deterioration of cognitive functions. The pathological hallmarks are extracellular deposits of amyloid plaques and intracellular neurofibrillary tangles of tau protein. The cognitive deficits seen are thought to be due to synaptic dysfunction and neurochemical deficiencies. Various neurochemical abnormalities have been observed during progressive ageing, and are linked to cognitive abnormalities as seen with the sporadic form of AD. Acetylcholinesterase inhibitors are one of the major therapeutic strategies used for the treatment of AD. During the last decade, various new therapeutic strategies have shown beneficial effects in preclinical studies and under clinical development for the treatment of AD. The present review is aimed at discussing the neurobiology of AD and association of neurochemical abnormalities associated with cognitive deterioration and new therapeutic strategies for the treatment of AD.
引用
收藏
页码：297 / 307
页数：11
相关论文
共 161 条
[1]   Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease [J].
Aboukhatwa, Marwa ;
Dosanjh, Laura ;
Luo, Yuan .
MOLECULAR NEURODEGENERATION, 2010, 5
[2]   Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder [J].
Abrams, Paul ;
Andersson, Karl-Erik ;
Buccafusco, Jerry J. ;
Chapple, Christopher ;
de Groat, William Chet ;
Fryer, Alison D. ;
Kay, Gary ;
Laties, Alan ;
Nathanson, Neil M. ;
Pasricha, Pankaj Jay ;
Wein, Alan J. .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (05) :565-578
[3]   5-hydroxytryptamine 6 receptor (5-HT6) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country [J].
Alvarez-Alvareza, M ;
Galdos, L ;
Fernández-Martínez, M ;
Gómez-Busto, F ;
García-Centeno, V ;
Arias-Arias, C ;
Sánchez-Salazar, C ;
Rodríguez-Martínez, AB ;
Zarranz, JJ ;
de Pancorbo, MM .
NEUROSCIENCE LETTERS, 2003, 339 (01) :85-87
[4]  
Alzheimer A., 1907, Zentralbl. Nervenh. Psych, V64, P146, DOI DOI 10.1002/CA.980080612
[5]  
Alzheimer's Association, 2016, Alzheimers Dement, V12, P459
[6]  
Alzheimers Association, 2015, Alzheimers Dement, V11, P332
[7]  
Anagnostaras S. G., 2002, NAT NEUROSCI, V6
[8]   Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer's Disease: A 7-Year Follow-up [J].
Annweiler, Cedric ;
Rolland, Yves ;
Schott, Anne M. ;
Blain, Hubert ;
Vellas, Bruno ;
Herrmann, Francois R. ;
Beauchet, Olivier .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2012, 67 (11) :1205-1211
[9]   N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody [J].
Antonios, Gregory ;
Saiepour, Nasrin ;
Bouter, Yvonne ;
Richard, Bernhard C. ;
Paetau, Anders ;
Verkkoniemi-Ahola, Auli ;
Lannfelt, Lars ;
Ingelsson, Martin ;
Kovacs, Gabor G. ;
Pillot, Thierry ;
Wirths, Oliver ;
Bayer, Thomas A. .
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2013, 1
[10]  
Aprioku Jonah Sydney, 2013, J Reprod Infertil, V14, P158
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