Transcriptional profiling of macrophages infected with Fonsecaea monophora

被引：11
作者：
Shi, Minglan [1 ,2 ,3 ]
Sun, Jiufeng [4 ]
Lu, Sha [1 ,3 ]
Qin, Jinglin [1 ,3 ]
Xi, Liyan [1 ,3 ]
Zhang, Junmin [1 ,3 ]
机构：
[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Dermatol & Venereol, Guangzhou, Guangdong, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Dept Dermatol & Venereol, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China
[4] Guangdong Prov Ctr Dis Control & Prevent, Guangdong Prov Inst Publ Hlth, Guangzhou, Guangdong, Peoples R China
来源：
MYCOSES | 2019年 / 62卷 / 04期
基金：
中国国家自然科学基金;
关键词：
MERISTEMATIC MUTANT; CHROMOBLASTOMYCOSIS; MELANIZATION; PEDROSOI; TAK1;
D O I：
10.1111/myc.12894
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Fonsecaea monophora is a member of dematiaceous fungi capable of causing chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between F. monophora and host. The aim of this study was to explore the potential mechanism of macrophages against F. monophora, especially the role of melanin during the pathogenic process. We carried out RNA sequencing based on the Illumina system. It showed that according to melanin contents, different strains of F. monophora induced different transcriptional profilings in macrophages. Functional analyses suggested the biological functions of differentially expressed genes were closely related to immune response, and the melanin might affect the interactions by regulating the MAPK signalling pathway of macrophages. Our results provide insights into the pathogenesis of infection by F. monophora conidia.
引用
收藏
页码：374 / 383
页数：10
相关论文
共 36 条
[1]   Toll-like receptor signalling [J].
Akira, S ;
Takeda, K .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511
[2]   Toll and Toll-like receptor signalling in development [J].
Anthoney, Niki ;
Foldi, Istvan ;
Hidalgo, Alicia .
DEVELOPMENT, 2018, 145 (09)
[3]   Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation [J].
Behrens, A ;
Sibilia, M ;
Wagner, EF .
NATURE GENETICS, 1999, 21 (03) :326-329
[4]   Inhibition of nitric oxide production by macrophages in chromoblastomycosis:: a role for Fonsecaea pedrosoi melanin [J].
Bocca, AL ;
Brito, PMS ;
Figueiredo, F ;
Tosta, CE .
MYCOPATHOLOGIA, 2006, 161 (04) :195-203
[5]   Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease [J].
Cao, Xuetao .
NATURE REVIEWS IMMUNOLOGY, 2016, 16 (01) :35-50
[6]   Role of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways in regulating replication of Penicillium marneffei in human macrophages [J].
Chen, Renqiong ;
Li, Xiqing ;
Lu, Sha ;
Ma, Than ;
Huang, Xiaowen ;
Mylonakis, Eleftherios ;
Liang, Yuheng ;
Xi, Liyan .
MICROBES AND INFECTION, 2014, 16 (05) :401-408
[7]   Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin [J].
da Gloria Sousa, Maria ;
Reid, Delyth M. ;
Schweighoffer, Edina ;
Tybulewicz, Victor ;
Ruland, Juergen ;
Langhorne, Jean ;
Yamasaki, Sho ;
Taylor, Philip R. ;
Almeida, Sandro R. ;
Brown, Gordon D. .
CELL HOST & MICROBE, 2011, 9 (05) :436-443
[8]   A case of cerebral phaeohyphomycosis caused by Fonsecaea monophora, a neurotropic dematiaceous fungus, and a review of the literature [J].
Doymaz, Mehmet Z. ;
Seyithanoglu, Mehmet F. ;
Hakyemez, Ismail ;
Gultepe, Bilge S. ;
Cevik, Serdar ;
Aslan, Turan .
MYCOSES, 2015, 58 (03) :187-192
[9]   Innate Defense against Fungal Pathogens [J].
Drummond, Rebecca A. ;
Gaffen, Sarah L. ;
Hise, Amy G. ;
Brown, Gordon D. .
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2015, 5 (06) :1-19
[10]   The role of Dectin-1 in the host defence against fungal infections [J].
Drummond, Rebecca A. ;
Brown, Gordon D. .
CURRENT OPINION IN MICROBIOLOGY, 2011, 14 (04) :392-399
1234