ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

被引：129

作者：

Pontes Oliveira de Almeida, Arthur Jose ^{[1
]}

Pinheiro Lucio de Oliveira, Julio Cesar ^{[1
]}

da Silva Pontes, Larisse Virgolino ^{[1
]}

de Souza Junior, Javanyr Frederico ^{[1
]}

Felisberto Goncalves, Tays Amanda ^{[1
]}

Dantas, Sabine Helena ^{[1
]}

de Almeida Feitosa, Mathania Silva ^{[1
]}

Silva, Antonia Oliveira ^{[2
]}

de Medeiros, Isac Almeida ^{[1
]}

机构：

[1] Univ Fed Paraiba, Ctr Ciencias Saude, Dept Ciencias Farmaceut, Cidade Univ Campus 1,Caixa Postal 5009, BR-58051970 Joao Pessoa, Paraiba, Brazil

[2] Univ Fed Paraiba, Ctr Ciencias Saude, Programa Posgrad Enfermagem, Cidade Univ Campus 1,Caixa Postal 5009, BR-58051970 Joao Pessoa, Paraiba, Brazil

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2022年 / 2022卷

关键词：

THIOREDOXIN-INTERACTING PROTEIN; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; GLUTATHIONE-PEROXIDASE; AUTOPHAGIC DEGRADATION; S-GLUTATHIONYLATION; KEAP1-NRF2; SYSTEM; HYPOCHLOROUS ACID; REDOX HOMEOSTASIS; NADPH OXIDASE;

D O I：

10.1155/2022/1225578

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of molecules with oxidizing properties known as ROS. Despite those molecules being implied negatively in aging and numerous diseases, their key role in cellular signaling is evident. ROS control several biological processes such as inflammation, proliferation, and cell death. The redox signaling underlying these cellular events is one characteristic of the new generation of scientists aimed at defining the role of ROS in the cellular environment. The control of redox potential, which includes the balance of the sources of ROS and the antioxidant system, implies an important target for understanding the cells' fate derived from redox signaling. In this review, we summarized the chemical, the redox balance, the signaling, and the implications of ROS in biological aging.

引用

页数：23

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