THE ROLE OF INTERFERON-GAMMA RELEASE ASSAY IN TUBERCULOSIS CONTROL

被引：5

作者：

Jurcev-Savicevic, Anamarija ^{[1
,2
]}

Katalinic-Jankovic, Vera ^{[3
]}

Mise, Kornelija ^{[2
,4
]}

Gudelj, Ivan ^{[2
,4
]}

机构：

[1] Univ Split, Teaching Publ Hlth Inst Split & Dalmatia Cty, Split, Croatia

[2] Univ Split, Sch Med, Split, Croatia

[3] Croatian Natl Inst Publ Hlth Zagreb, Zagreb, Croatia

[4] Univ Split, Split Univ Hosp, Dept Pulm Dis, Split, Croatia

来源：

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY | 2012年 / 63卷 / 01期

关键词：

Croatia; enzyme-linked immunospot assay; latent tuberculosis infection; QuantiFERON-TB; Go/din-Tube; tuberculin skin test; QUANTIFERON-TB-GOLD; HEALTH-CARE WORKERS; WITHIN-SUBJECT VARIABILITY; LATENT TUBERCULOSIS; SKIN-TEST; ACTIVE TUBERCULOSIS; COST-EFFECTIVENESS; OCCUPATIONAL RISK; TUBE ASSAY; FOLLOW-UP;

D O I：

10.2478/10004-1254-63-2012-2134

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Tuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation. Therefore, it is important to identify and effectively treat those individuals who have latent tuberculosis infection and who may develop active disease. The tuberculin skin test has been the standard for detection of immune response against M tuberculosis since the beginning of the 20(th) century. The new millennium has brought advancement in the diagnosis of latent tuberculosis infection. The name of the new blood test is interferon-gamma release assay (IGRA). Croatia is a middle-incidence country with a long decreasing trend and developed tuberculosis control. To reach low incidence and finally eliminate tuberculosis, its tuberculosis programme needs a more aggressive approach that would include intensive contact investigation and treatment of persons with latent tuberculosis infection. This article discusses the current uses of IGRA and its role in tuberculosis control.

引用

页码：49 / 59

页数：11

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