Role of chemokines, innate and adaptive immunity

被引：38

作者：

Zimmerman, Kurt A. ^{[1
,2
]}

Hopp, Katharina ^{[3
]}

Mrug, Michal ^{[4
,5
]}

机构：

[1] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA

[2] Univ Oklahoma, Dept Internal Med, Div Nephrol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

[3] Univ Colorado, Div Renal Dis & Hypertens, Polycyst Kidney Dis Program, Dept Med, Anschutz Med Campus, Aurora, CO 80045 USA

[4] Univ Alabama Birmingham, Dept Med, Div Nephrol, Birmingham, AL 35294 USA

[5] Dept Vet Affairs Med Ctr, Birmingham, AL 35233 USA

来源：

CELLULAR SIGNALLING | 2020年 / 73卷

基金：

美国国家卫生研究院;

关键词：

Autosomal dominant polycystic kidney disease ADPKD; Autosomal recessive polycystic kidney disease ARPKD; Immune response; Chemokines; Macrophages; T cells; Kidney function; POLYCYSTIC KIDNEY-DISEASE; REGULATORY T-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; TUMOR-NECROSIS-FACTOR; B-CELLS; DENDRITIC CELL; GENE-EXPRESSION; RENAL INJURY; ACCELERATES CYSTOGENESIS; ANTIGEN PRESENTATION;

D O I：

10.1016/j.cellsig.2020.109647

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycystic Kidney Disease (PKD) triggers a robust immune system response including changes in both innate and adaptive immunity. These changes involve immune cells (e.g., macrophages and T cells) as well as cytokines and chemokines (e.g., MCP-1) that regulate the production, differentiation, homing, and various functions of these cells. This review is focused on the role of the immune system and its associated factors in the pathogenesis of PKDs as evidenced by data from cell-based systems, animal models, and PKD patients. It also highlights relevant pre-clinical and clinical studies that point to specific immune system components as promising candidates for the development of prognostic biomarkers and therapeutic strategies to improve PKD outcomes.

引用

页数：15