A clubbed quinazolinone and 4-thiazolidinone as potential antimicrobial agents

被引：18
作者：
Desai, N. C. [1 ]
Dodiya, Amit M. [1 ]
Shihora, Prashant N. [1 ]
机构：
[1] Bhavnagar Univ, Dept Chem, Div Med Chem, Bhavnagar 364002, Gujarat, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 08期
关键词：
Quinazolinone; 4-Thiazolidinone; Antimicrobial activity; BIOLOGICAL-ACTIVITY; DERIVATIVES; ANTIBACTERIAL;
D O I：
10.1007/s00044-011-9674-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of N-{5-[(2-chlorophenyl)methylene]-2-(4-hydroxyphenyl]-4-oxo(1,3-thiazolidin-3-yl)}{4-[2-(4-methylphenyl)-4-oxo(3-hydroquinazolin-3-yl)]phenyl}carboxamides (6a-n) have been synthesized. All the synthesized compounds were screened for in vitro antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger, and Aspergillus clavatus. The structures of the compounds were elucidated by IR, H-1 NMR, C-13 NMR, and Mass spectra.
引用
收藏
页码：1577 / 1586
页数：10
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