Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms

被引：65

作者：

Eccles, J. A. ^{[1
,2
]}

Beacher, F. D. C. ^{[1
]}

Gray, M. A. ^{[1
]}

Jones, C. L. ^{[1
]}

Minati, L. ^{[1
]}

Harrison, N. A. ^{[1
,3
,4
]}

Critchley, H. D. ^{[1
,3
,4
]}

机构：

[1] Brighton & Sussex Med Sch, Dept Psychiat, Brighton BN1 9RR, E Sussex, England

[2] Sussex Partnership Natl Hlth Serv NHS Fdn Trust, Sussex Educ Ctr, Hove, England

[3] Sussex Partnership NHS Fdn Trust, Sussex Educ Ctr, Hove, England

[4] Univ Sussex, Sackler Ctr Consciousness Sci, Brighton, E Sussex, England

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2012年 / 200卷 / 06期

基金：

英国惠康基金;

关键词：

PANIC DISORDER; ANXIETY;

D O I：

10.1192/bjp.bp.111.092460

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Joint hypermobility is overrepresented among people with anxiety and can be associated with abnormal autonomic reactivity. We tested for associations between regional cerebral grey matter and hypermobility in 72 healthy volunteers using voxel-based morphometry of structural brain scans. Strikingly, bilateral amygdala volume distinguished those with from those without hypermobility. The hypermobility group scored higher for interoceptive sensitivity yet were not significantly more anxious. Our findings specifically link hypermobility to the structural integrity of a brain centre implicated in normal and abnormal emotions and physiological responses. Our observations endorse hypermobility as a multisystem phenotype and suggest potential mechanisms mediating clinical vulnerability to neuropsychiatric symptoms.

引用

页码：508 / 509

页数：2

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