Not all that glitters is gold

被引:0
作者
Gazitt, Y [1 ]
机构
[1] Univ Texas, Hlth Sci Ctr, San Antonio, TX 78284 USA
关键词
D O I
10.1182/blood-2005-09-3835
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Multiple myeloma (MM) is a difficult disease to treat because of confounding factors such as genetic heterogeneity and the multiplicity and redundancy of survival pathways constitutively activated in this disease.
引用
收藏
页码:4025 / 4026
页数:2
相关论文
共 7 条
[1]   Nuclear factor-κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis [J].
Bharti, AC ;
Shishodia, S ;
Reuben, JM ;
Weber, D ;
Alexanian, R ;
Raj-Vadhan, S ;
Estrov, Z ;
Talpaz, M ;
Aggarwal, BB .
BLOOD, 2004, 103 (08) :3175-3184
[2]   Phase I and pharmacokinetic study of the oral farnesyl transferase inhibitor SCH 66336 given twice daily to patients with advanced solid tumors [J].
Eskens, FALM ;
Awada, A ;
Cutler, DL ;
de Jonge, MJA ;
Luyten, GPM ;
Faber, MN ;
Statkevich, P ;
Sparreboom, A ;
Verweij, J ;
Hanauske, AR ;
Piccart, M .
JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (04) :1167-1175
[3]   Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma [J].
Hideshima, T ;
Chauhan, D ;
Hayashi, T ;
Akiyama, M ;
Mitsiades, N ;
Mitsiades, C ;
Podar, K ;
Munshi, NC ;
Richardson, PG ;
Anderson, KC .
ONCOGENE, 2003, 22 (52) :8386-8393
[4]   3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells [J].
Kulp, SK ;
Yang, YT ;
Hung, CC ;
Chen, KF ;
Lai, JP ;
Tseng, PH ;
Fowble, JW ;
Ward, PJ ;
Chen, CS .
CANCER RESEARCH, 2004, 64 (04) :1444-1451
[5]   Clinical update: proteasome inhibitors in hematologic malignancies [J].
Richardson, P .
CANCER TREATMENT REVIEWS, 2003, 29 :33-39
[6]   Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-κB activation through inhibition of activation of IκBα kinase and Akt in human non-small cell lung carcinoma:: Correlation with suppression of COX-2 synthesis [J].
Shishodia, S ;
Koul, D ;
Aggarwal, BB .
JOURNAL OF IMMUNOLOGY, 2004, 173 (03) :2011-2022
[7]   Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-κB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-κB-regulated gene expression and up-regulation of apoptosis [J].
Takada, Y ;
Khuri, FR ;
Aggarwal, BB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (25) :26287-26299