Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study

被引:79
作者
Peter, I
Shearman, AM
Zucker, DR
Schmid, CH
Demissie, S
Cupples, LA
Larson, MG
Vasan, RS
D'Agostino, RB
Karas, RH
Mendelsohn, ME
Housman, DE
Levy, D
机构
[1] Tufts Univ, New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA
[2] MIT, Biostat Res Ctr, Inst Clin Res & Hlth Policy Studies, Cambridge, MA 02139 USA
[3] MIT, Ctr Canc Res, Cambridge, MA 02139 USA
[4] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA
[5] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
[6] NHLBI, Framingham, MA USA
关键词
polymorphism (genetics); receptors; estrogen; hypertension; blood pressure; association; epidemiology;
D O I
10.1097/01.hjh.0000188728.66183.92
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objective To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women. Design In 1780 unrelated members of the community-based Framingham Heart Study offspring cohort, systolic blood pressure and diastolic blood pressure were measured over a total of six examination cycles encompassing 24 years of follow-up. Multivariate regression analyses were used to assess the relation between untreated cross-sectional and longitudinal blood pressure and polymorphisms at the estrogen receptor-a (ESR1), estrogen receptor-beta (ESR2), aromatase (CYP19A1), and nuclear receptor coactivator 1 (NCOA1) genes after adjustment for common risk factors. Results In men, systolic blood pressure and pulse pressure (systolic blood pressure minus diastolic blood pressure) were associated with two polymorphisms in ESR1, while pulse pressure was also associated with variations in NCOA1 and CYP19A1. Polymorphisms in ESR1, CYP19A1, and NCOA1 were associated with diastolic blood pressure in women. Conclusions Although the underlying relations between genes involved in estrogen action and hypertension remain to be completely understood, our findings provide suggestive evidence of gender-specific contributions of estrogen-related genes to blood pressure variation. As no correction for multiple testing was performed in the analyses, we view these results as suggestive and not definitive. Further studies are warranted to confirm these results using a comprehensive set of polymorphisms in order to shed more light on the involvement of estrogen in blood pressure regulation.
引用
收藏
页码:2193 / 2200
页数:8
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