The complex role of vitamin D in autoimmune diseases

被引：149

作者：

Szodoray, P. ^{[1
]}

Nakken, B. ^{[2
]}

Gaal, J. ^{[3
]}

Jonsson, R. ^{[4
,5
]}

Szegedi, A. ^{[6
]}

Zold, E. ^{[1
]}

Szegedi, G. ^{[1
,7
]}

Brun, J. G. ^{[5
]}

Gesztelyi, R. ^{[8
]}

Zeher, M.

Bodolay, E. ^{[1
]}

机构：

[1] Univ Debrecen, Dept Med 3, Div Clin Immunol, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Dept Biochem & Mol Biol, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

[3] Kenezy Cty Hosp, Dept Rheumatol, Debrecen, Hungary

[4] Univ Bergen, Gade Inst, Broegelmann Res Lab, N-5020 Bergen, Norway

[5] Univ Bergen, Haukeland Univ Hosp, Dept Rheumatol, Bergen, Norway

[6] Univ Debrecen, Dept Dermatol, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

[7] Hungarian Acad Sci, Res Grp Autoimmune Dis, Budapest, Hungary

[8] Univ Debrecen, Dept Pharmacol, Med & Hlth Sci Ctr, Fac Pharm, H-4032 Debrecen, Hungary

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2008年 / 68卷 / 03期

关键词：

D O I：

10.1111/j.1365-3083.2008.02127.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.

引用

页码：261 / 269

页数：9

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