Molecular anatomy of mouse hepatitis virus persistence: Coevolution of increased host cell resistance and virus virulence

被引:88
作者
Chen, W
Baric, RS
机构
[1] UNIV N CAROLINA, DEPT EPIDEMIOL, PROGRAM INFECT DIS, CHAPEL HILL, NC 27599 USA
[2] UNIV N CAROLINA, DEPT MICROBIOL & IMMUNOL, CHAPEL HILL, NC 27599 USA
关键词
D O I
10.1128/JVI.70.6.3947-3960.1996
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Persistent infection of murine astrocytoma (DBT) cells with mouse hepatitis virus (MHV) has been established. From this in vitro virus-host system, persistence is mediated at the level of cellular MHV receptor (MHVR) expression and increased virus virulence. MHV persistence selects for resistant host cell populations which abate virus replication. Reductions in MHVR expression were significantly associated with increased host resistance, and transfection of MHVR into resistant host cells completely restored the capacity of cells to support efficient replication of MHV strain A59. The emergence of resistant host cells coselected for variant viruses that had increased avidity for MHVR and also recognized different receptors for entry into resistant cells. These data illustrate that MHV persistence in vitro provides a model to identify critical sites of virus-host interaction at the cellular level which are altered during the evolution of host cell resistance to viral infection and the coevolution of virus virulence.
引用
收藏
页码:3947 / 3960
页数:14
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