Low-density lipoprotein as a biomarker for the mobilization of hematopoietic stem cells in peripheral blood

被引：6
作者：
Ishihara, Tomoko [1 ]
Mishima, Seiji [1 ]
Kodama, Rumi [1 ]
Yoshino, Isao [1 ]
Adachi, Erika [1 ]
Suyama, Tamiko [1 ]
Shibata, Hiroshi [1 ]
Taketani, Takeshi [2 ]
Nagai, Atsushi [1 ]
机构：
[1] Shimane Univ Hosp, Cent Clin Lab, Izumo, Shimane 6938501, Japan
[2] Shimane Univ Hosp, Div Blood Transfus, Izumo, Shimane 6938501, Japan
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2013年 / 49卷 / 03期
关键词：
LDL; Cholesterol; Hematopoietic stem cell; Mobilization; PBSCH; BONE-MARROW; RANDOMIZED-TRIAL; G-CSF; TRANSPLANTATION; HYPERCHOLESTEROLEMIA; MECHANISMS;
D O I：
10.1016/j.transci.2013.07.033
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The predictor of hematopoietic stem cells (HSCs) mobilized in peripheral blood (PB) remains unknown. We retrospectively examined the relationship between serum cholesterol level and CD34-positive cells mobilized with granulocyte stimulating factor in PB. PB- mobilized CD34-positive cells were significantly higher in patients with high titers of total cholesterol and low-density lipoprotein cholesterol (LDL-C) than in patients with normal levels (average total cholesterol, 122.94 vs. 51.03/mu L, p < 0.05; average LDL-C 130.07 vs. 53.77, p < 0.05). Multivariable analysis showed that LDL-C significantly influenced PB-mobilized CD34-positive cells, suggesting that LDL-C may be an effective biomarker for mobilization of HSCs in PB. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：539 / 541
页数：3
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