Effects of Berberine against Pancreatitis and Pancreatic Cancer

被引：20
作者：
Vlavcheski, Filip [1 ,2 ]
O'Neill, Eric J. [1 ]
Gagacev, Filip [1 ]
Tsiani, Evangelia [1 ,2 ]
机构：
[1] Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada
[2] Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada
来源：
MOLECULES | 2022年 / 27卷 / 23期
关键词：
pancreatitis; berberine; polyphenols; pancreatic cancer; in vitro; in vivo; ENDOPLASMIC-RETICULUM STRESS; RISK-FACTORS; INTRAEPITHELIAL NEOPLASIA; ENDOSCOPIC ULTRASOUND; SIDE POPULATION; ACINAR-CELLS; IN-VITRO; ACTIVATION; ADENOCARCINOMA; DIAGNOSIS;
D O I：
10.3390/molecules27238630
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pancreas is a glandular organ with endocrine and exocrine functions necessary for the maintenance of blood glucose homeostasis and secretion of digestive enzymes. Pancreatitis is characterized by inflammation of the pancreas leading to temporary or permanent pancreatic dysfunction. Inflammation and fibrosis caused by chronic pancreatitis exacerbate malignant transformation and significantly increase the risk of developing pancreatic cancer, the world's most aggressive cancer with a 5-year survival rate less than 10%. Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation. The current review summarizes the existing in vitro and in vivo evidence on the effects of BBR against pancreatitis and pancreatic cancer with a focus on the signalling mechanisms underlying the effects of BBR.
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页数：24
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