The Bax pore in liposomes, biophysics

被引：28
作者：
Schlesinger, P. H. [1 ]
Saito, M. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Physiol & Cell Biol, St Louis, MO 63110 USA
来源：
CELL DEATH AND DIFFERENTIATION | 2006年 / 13卷 / 08期
关键词：
apoptosis; Bax; cytochrome c; pore;
D O I：
10.1038/sj.cdd.4401991
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.
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收藏
页码：1403 / 1408
页数：6
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