Effectiveness of Antiplatelet Drugs Under Therapeutic Hypothermia: A Comprehensive Review

被引：11

作者：

Eyileten, Ceren ^{[1
]}

Soplinska, Aleksandra ^{[1
]}

Pordzik, Justyna ^{[1
]}

Siller-Matula, Olanta M. ^{[2
]}

Postula, Marek ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Expt & Clin Pharmacol, Ctr Preclin Res & Technol CEPT, Warsaw, Poland

[2] Med Univ Vienna, Dept Cardiol, Vienna, Austria

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2019年 / 106卷 / 05期

关键词：

HOSPITAL CARDIAC-ARREST; TARGETED TEMPERATURE MANAGEMENT; PERCUTANEOUS CORONARY INTERVENTION; ACUTE MYOCARDIAL-INFARCTION; PLATELET REACTIVITY; COMATOSE SURVIVORS; CARDIOGENIC-SHOCK; CLOPIDOGREL; TICAGRELOR; PRASUGREL;

D O I：

10.1002/cpt.1492

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Out-of-hospital cardiac arrest is among the most frequent causes of death worldwide. Immediate intervention, as well as dual antiplatelet therapy consisting of acetylsalicylic acid and a P2Y(12) inhibitor is often recommended. In line with the growing number of reports on cardiac arrest treatment, therapeutic hypothermia (TH) has been proposed for unconscious patients to improve neurological outcomes. Nevertheless, studies report controversial and often discrepant results on the effect of hypothermia on blood coagulability and platelet reactivity. In this review, we summarize the knowledge on platelet function under diverse hypothermic conditions. Additionally, we review the current literature on the effect of systemic hypothermia on pharmacokinetic and pharmacodynamic properties of antiplatelet agents. It has been shown that TH can alter the effectiveness of antiplatelet agents, including P2Y(12) inhibitors, through multiple mechanisms, hence, special attention should be paid while implementing antiplatelet therapy in patients under TH conditions.

引用

页码：993 / 1005

页数：13

共 100 条

[1] Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations [J].