An efficient and recyclable 3D printed α-Al2O3 catalyst for the multicomponent assembly of bioactive heterocycles

被引：83

作者：

Azuaje, Jhonny ^{[1
,2
,4
]}

Tubio, Carmen R. ^{[3
]}

Escalante, Luz ^{[1
,2
]}

Gomez, Monica ^{[3
]}

Guitian, Francisco ^{[3
]}

Coelho, Alberto ^{[1
,2
,4
]}

Caamano, Olga ^{[2
,4
]}

Gil, Alvaro ^{[3
]}

Sotelo, Eddy ^{[1
,2
,4
]}

机构：

[1] Univ Santiago de Compostela, Ctr Singular Invest Quim Biol & Mat Mol CIQUS, E-15782 Santiago De Compostela, Spain

[2] Univ Santiago de Compostela, Fac Farm, Dept Quim Organ, E-15782 Santiago De Compostela, Spain

[3] Univ Santiago de Compostela, Inst Ceram, E-15782 Santiago De Compostela, Spain

[4] Univ Santiago de Compostela, IFI, E-15782 Santiago De Compostela, Spain

来源：

APPLIED CATALYSIS A-GENERAL | 2017年 / 530卷

关键词：

3D printing; Al2O3; Multicomponent reactions; 1,4-Dihydropyrimidines; 3,4-Dihydropyrimidin-2(1H)-ones; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; GREEN CHEMISTRY; GAMMA-ALUMINA; 4-COMPONENT SYNTHESIS; ETHANOL DEHYDRATION; MESOPOROUS ALUMINA; LEWIS ACIDITY; SOLVENT-FREE; ONE-POT; SURFACE;

D O I：

10.1016/j.apcata.2016.11.031

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A catalytic methodology is reported that enables the efficient, operationally simple and environmentally friendly synthesis of diverse 1,4-dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones, including some relevant drugs and pharmacologically active derivatives. This strategy is based on the use of a 3D printed Al2O3 woodpile material that was sintered to generate a rigid structure with controlled porosity and noteworthy catalytic performance. The 3D printed Al2O3 catalyst exhibits remarkable efficacy as a Lewis acid in Biginelli and Hantzsch reactions and it can be recovered and reused ten times without any decrease in the activity. Remarkable E factors, excellent recyclability and scalability, broad substrate scope, short reaction times, excellent yields, solvent-free conditions and easy isolation procedures are key features of this methodology. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：203 / 210

页数：8

共 85 条

[41] Chemistry of alumina, reactions in aqueous solution and its application in water treatment [J].